Intratumoral oxygen tension in metastatic melanoma
Intratumoral oxygen tension in metastatic melanoma
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DOI：
10.1097/00008390-199710000-00006
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发表时间：
1997-10-01
影响因子：
2.2
通讯作者：
Guichard, M
中科院分区：
文献类型：
--
作者：
Lartigau, E;Randrianarivelo, H;Guichard, M
肿瘤缺氧可导致辐射和烷基化剂的生物有效性降低。关于黑色素瘤的氧张力（PO2）数据很少。在20例既往有黑色素瘤病史的患者中，对正常组织和疑似转移灶（淋巴结和皮肤转移灶）中的PO2进行了评估。在手术切除疑似转移灶前一天，使用针探针技术（KIMOC-6650直方图，Eppendorf，德国）测量氧张力。组织学证实18例切除病变的恶性起源。在两个病例中，组织学上未见已知黑色素瘤的侵袭。正常组织的中位PO2为40.5 mmHg。对于肿瘤，PO2中位数为11.6 mmHg，淋巴结为17.1 mmHg，皮肤转移为6.7 mmHg。极低值（< 2 mmHg）占淋巴结记录值的20%，皮肤转移的15%。当根据淋巴结大小（直径<或大于或等于3cm）进行分析时，大淋巴结（6例）的中位PO2为10.4 mmHg，小淋巴结（6例）的中位PO2为53.3 mmHg。对于两个非肿瘤病变，PO2中位值分别为20.9和25.1 mmHg，没有低于10 mmHg的值。因此，与正常组织相比，在大多数转移性肿瘤中发现PO2值降低，可能与肿瘤缺氧相对应。这些PO2测量在黑色素瘤中的预后价值仍有待于在肿瘤对放疗或烷基化剂的反应中得到证实。然而，肿瘤缺氧已经可以作为转移性黑色素瘤新治疗方式的靶点进行研究。
Tumour hypoxia can lead to a decrease in the biological effectiveness of radiation and alkylating agents. Few data are available on oxygen tension (PO2) in melanoma. In 20 patients with past history of melanoma, PO2 was evaluated in normal tissues and suspected metastatic lesions (nodes and skin metastases). Oxygen tension was measured using a needle probe technique (KIMOC-6650 histograph, Eppendorf, Germany), the day before the surgical removal of the suspected metastatic lesion. Histological confirmation of the malignant origin of the removed lesion was obtained in 18 cases. In two cases invasion by the known melanoma was not seen histologically. The median PO2 for normal tissues was 40.5 mmHg. For tumours, the median PO2 was 11.6 mmHg, and it was 17.1 mmHg in nodes and 6.7 mmHg in skin metastases. Very low values (< 2 mmHg) accounted for 20% of the recorded values in nodes and 15% in skin metastases. when analysed according to the node size (< or greater than or equal to 3 cm in diameter), the median PO2 was 10.4 mmHg in large nodes (six patients) and 53.3 mmHg in small nodes (six patients). For the two non-tumoral lesions, the median PO2 values were 20.9 and 25.1 mmHg, with no values below 10 mmHg. Thus a decrease in PO2 values, probably corresponding to tumour hypoxia, was found in most of the metastatic tumours when compared with normal tissues. The prognostic value of these PO2 measurements in melanoma remains to be demonstrated in the tumour response to radiotherapy or alkylating agents. However, tumour hypoxia can already be investigated as a target for new treatment modalities in metastatic melanoma.