Silica sulfuric acid mediated synthesis of naphtho[2,1-b]furan derivatives and development of one-pot multicomponent synthesis of substituted pyrazole derivatives
Silica sulfuric acid mediated synthesis of naphtho[2,1-b]furan derivatives and development of one-pot multicomponent synthesis of substituted pyrazole derivatives
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DOI：
10.1002/jhet.4280
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发表时间：
2021-05-11
影响因子：
2.4
通讯作者：
Sunkara, Satya Veni
中科院分区：
文献类型：
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作者：
Uppalapati, Divya Sree;Dachuru, Rama Sekhara Reddy;Sunkara, Satya Veni
在硅酸(SSA)催化下，以β-硝基苯衍生物和β-萘酚衍生物为起始原料，在无溶剂条件下合成了萘并[2，1-b]呋喃衍生物。将SSA作为非均相催化剂的范围扩展到一锅多组分反应，用于在无溶剂的条件下以现成的β-硝基苯乙烯衍生物、乙酰丙酮和水合肼为原料合成功能化的吡唑衍生物。该合成方法具有条件无溶剂、操作简单、反应时间短、分离步骤简便、产品收率高等显著优点。
Silica sulfuric acid (SSA) mediated synthesis of naphtho[2,1-b]furan derivatives starting from beta-nitrostyrene derivatives and beta-naphthol derivatives under solvent-free conditions have been developed. The scope of SSA as a heterogeneous catalyst is extended to one-pot multicomponent reaction for the synthesis of functionalized pyrazole derivatives under solvent-free conditions from readily available beta-nitrostyrene derivatives, acetyl acetone, and hydrazine hydrate. The synthetic methods have significant advantages such as solvent-free conditions, simple operation, shorter reaction times, ease and clean isolation procedures, and very good yields of products.