Development of the short-tailed mutant in the house mouse
Development of the short-tailed mutant in the house mouse
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DOI：
10.1002/jez.1400700306
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发表时间：
1935-05-01
影响因子：
--
通讯作者：
Chesley, P
中科院分区：
文献类型：
--
作者：
Chesley, P
短尾的遗传特性在纯合条件下是致死的。携带此复合体的胚胎表现出以下异常：在体节早期脊索减少，在后期缺乏。在早期阶段出现背侧隆起的水泡。神经管有许多分支。体节大大减少和不规则。后端不发育。固缩颗粒，表明细胞退化，存在于原始条纹和相关结构中。纯合子胚胎通常在达到11天之前死亡。杂合子动物的特征是出生后尾巴缩短，在发育12天时尾巴的长度与正常胚胎的尾巴相等。然而，尾巴的远端仅由分段的细丝表示。神经管和脊索在此纤维近端异常，但不进入此纤维。脊索在腰骶部产生异常憩室。这里的神经管正常从这些事实和实验结果来看。在两栖动物和小鸡身上，可以得出结论：在老鼠身上，脊索对神经管有形成的影响。其他研究小鸡和两栖类的工作者已经得出了这样的结论。
The genetic character for short-tail is lethal in the homozygous condition. Embryos carrying this complex show the following ab-normalies: The notochord is reduced in the early somite stage and lacking in later stages. Blisters of the dorsal eplthelium occur in early stages. The neural tube shows numerous side branches. Somites are greatly reduced and irregular. The posterior end does not develop. Pycnotic granules, indicating cellular degeneration, are present in the primitive streak and associated structures. Homo-zygous embryos regularly die just before reaching 11 days of age. Heterozygous animals, which are characterized postnatally by a shortened tail, have tails equal in length to those of normal embryos at 12 days'' development. The distal end of the tail is represented only by a segmented filament, however. The neural tube and notochord are abnormal just proximal to this filament and do not enter it. The notochord produces abnormal diverticula in the lumbosacral region. The neural tube is normal here. From these facts and from the results of the exps. on amphibians and the chick it is concluded that in the mouse the notochord has a formative influence upon the neural tube. Such a conclusion has already been reached by other workers for the chick and Amphibia.