Activation of glycoyl trihaloacetimidates with acid-washed molecular sieves in the glycosidation reaction
Activation of glycoyl trihaloacetimidates with acid-washed molecular sieves in the glycosidation reaction
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DOI：
10.1021/ol027353i
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发表时间：
2003-04-03
期刊：
影响因子：
5.2
通讯作者：
Schiattarella, M
中科院分区：
文献类型：
--
作者：
Adinolfi, M;Barone, G;Schiattarella, M
[图]市售的4 Angstrom酸洗分子筛(4 Angstrom AW 300 MS)是糖基三氯乙酸乙酯和N-苯基三氟乙酸乙酯的有效活化剂。这些促进剂使得初级和次级糖类受体的糖苷化可以在非常温和的条件下以高产率进行，并且通过实验简单的步骤进行。此外，这类促进剂的可回收性也得到了证明。
[GRAPHIC]Commercially available 4 Angstrom acid washed molecular sieves (4 Angstrom AW 300 MS) are efficient activators of glycosyl trichloro- and N-phenyltrifluoroacetimidates. These promoters allow glycosidation of primary and secondary saccharidic acceptors to be performed in high yield, under very mild conditions and by an experimentally simple procedure. In addition, the recyclability of such promoters also has been demonstrated.