Conduct disorder with and without mania in a referred sample of ADHD children
Conduct disorder with and without mania in a referred sample of ADHD children
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DOI：
10.1016/s0165-0327(97)00043-8
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发表时间：
1997-07-01
影响因子：
6.6
通讯作者：
George, P
中科院分区：
文献类型：
--
作者：
Biederman, J;Faraone, SV;George, P
目的：验证焦虑型和非焦虑型CD在熟悉性、逆境和共病模式上的区别。方法：我们从多个领域对140名ADHD和120名正常对照进行了基线和4年后的评估。我们比较了有无品行障碍(CD)和双相情感障碍(BPD)的ADHD亚组在4年的随访中的精神结局、家庭精神病理学和心理社会功能。结果：我们发现，患有这两种障碍的ADHD儿童患情绪障碍的家庭和个人风险高于仅患有CD的儿童，后者患反社会人格障碍的个人风险更高。在ADHD先证者中，同时患有CD和BPD与功能较差和精神科住院风险增加有关。讨论：虽然是初步的，但我们的研究结果表明，焦虑型和非焦虑型CD之间的区别可能具有临床意义。如果得到证实，我们的发现可能对反社会青年的管理具有重要的诊断和治疗意义。(C)1997年爱思唯尔科学公司。
Objective: To test the hypothesis that dysphoric and non-dysphoric types of CD could be distinguished from one another in their patterns of familiality, adversity, and comorbidity. Methods: We examined 140 ADHD and 120 normal controls at baseline and 4 years later using assessments from multiple domains. We compared ADHD subgroups with and without conduct (CD) and bipolar (BPD) disorders on psychiatric outcomes at a 4-year follow-up, familial psychopathology and psychosocial functioning. Results: We found that ADHD children with both disorders had higher familial and personal risk for mood disorders than those with CD only, who had a higher personal risk for antisocial personality disorder. Among ADHD probands, having both CD and BPD was associated with poorer functioning and an increased risk for psychiatric hospitalization. Discussion: Although preliminary, our findings suggest that the distinction between dysphoric and non-dysphoric CD may be clinically meaningful. If confirmed, our findings could have important diagnostic and therapeutic implications for the management of antisocial youth. (C) 1997 Elsevier Science B.V.