The Papillomavirus Virion: A Machine Built to Hide Molecular Achilles' Heels
The Papillomavirus Virion: A Machine Built to Hide Molecular Achilles' Heels
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DOI：
10.1007/978-1-4614-0980-9_18
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Trus, Benes L.
中科院分区：
文献类型：
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作者：
Buck, Christopher B.;Trus, Benes L.
乳头瘤病毒是一组不同的DNA病毒，可以感染脊椎动物的皮肤和粘膜组织。到目前为止，已经确认了100多种不同的人类乳头瘤病毒(HPV)基因类型。已知HPV的一个子集会导致人类癌症。尽管最近开发的疫苗可以保护接种疫苗的人免受两种最具致癌性的HPV类型的影响，但迫切需要下一代疫苗，这种疫苗可能会对各种致癌HPV提供广谱保护。深入了解无包膜乳头瘤病毒病毒粒子的组装机制，以及病毒粒子在感染进入宿主细胞过程中发生的机器样结构变化，将有助于此类疫苗的持续开发。本章回顾了该领域对乳头瘤病毒生物学这两个方面的当前知识，并推测了需要进一步工作的领域。
Papillomaviruses are a diverse group of DNA viruses that infect the skin and mucosal tissues of vertebrates. More than 100 distinct human papillomavirus (HPV) genotypes have so far been identified. A subset of HPVs is known to cause human cancer. Although recently developed vaccines protect vaccinated individuals from the two most carcinogenic HPV types, there is a pressing need for next-generation vaccines that might offer broad-spectrum protection against the full range of cancer-causing HPVs. The ongoing development of such vaccines will be facilitated by a deeper understanding of the mechanics of the assembly of the nonenveloped papillomavirus virion, as well as the machinelike structural changes that occur in the virion during the process of infectious entry into host cells. This chapter reviews the field's current knowledge of these two aspects of papillomavirus biology and speculates about areas where further work is needed.