Short- and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes.
Short- and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes.
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血管紧张素 II 受体阻断对实验性糖尿病大鼠的短期和长期影响。
DOI：
--
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发表时间：
1993
影响因子：
13.6
通讯作者：
G. Remuzzi
中科院分区：
文献类型：
--
作者：
A. Remuzzi;N. Perico;C. Amuchastegui;B. Malanchini;M. Mazerska;C. Battaglia;T. Bertani;G. Remuzzi
研究了特异性血管紧张素II （AII）受体阻断对中度高血糖糖尿病大鼠肾小球损伤的短期和长期影响。采用三组动物，一组为对照组，一组为胰岛素治疗的糖尿病大鼠，另一组为胰岛素治疗的糖尿病大鼠，在饮用水中给予AII受体拮抗剂氯沙坦。观察4 ~ 6周后，糖尿病大鼠收缩压和GFR均高于正常对照组。氯沙坦治疗可防止收缩压和GFR升高。另外三组大鼠，同样治疗1年，用于肾功能和形态学评估。糖尿病动物尿蛋白排泄量和肾小球硬化发生率均高于正常对照组。氯沙坦可显著预防蛋白尿和肾小球硬化。通过Ficoll分级清除率对肾小球膜筛分特性的评估显示，与对照组相比，糖尿病动物中该标记物的过滤显著增加，并且在氯沙坦治疗的动物中几乎完全阻止了这种变化。用肾小球大小选择性异孔模型对分级清除率数据进行理论分析表明，与对照组相比，糖尿病动物的膜孔大小均匀增加。这些变化被AII受体拮抗剂完全阻止。本研究的结果有力地表明，AII活性的降低在肾小球结构和功能的保存中起着至关重要的作用，并表明先前在该模型中观察到的血管紧张素转换酶抑制的有利作用直接依赖于AII活性的降低。
The short- and long-term effects of specific angiotensin II (AII) receptor blockade on the evaluation of glomerular injury in moderately hyperglycemic diabetic rats were studied. Three groups of animals were used, a control group, a group of diabetic rats treated with insulin, and a group of insulin-treated diabetic rats receiving the AII receptor antagonist losartan in drinking water. After 4 to 6 wk of observation, diabetic rats showed higher systolic blood pressure and GFR than normal controls. Losartan treatment prevented both systolic blood pressure and GFR rise. Three other groups of rats, similarly treated for a 1-yr period, were used for renal functional and morphologic evaluation. Diabetic animals had higher urinary protein excretion and glomerulosclerosis incidence than did normal controls. Losartan significantly prevented proteinuria and glomerulosclerosis. Evaluation of the sieving properties of the glomerular membrane by Ficoll fractional clearance showed an important increase in the filtration of this marker in diabetic animals, as compared with that in controls, and almost complete prevention of this change in losartan-treated animals. Theoretical analysis of fractional clearance data with a heteroporous model of glomerular size-selectivity showed that in diabetic animals the size of membrane pores was increased uniformly, as compared with that in controls. These changes were completely prevented by the AII receptor antagonist. The results presented here strongly indicate that reduction of AII activity plays a crucial role in the preservation of glomerular structure and function and suggest that the favorable effects previously observed with angiotensin-converting enzyme inhibition in this model depend directly on the reduction of AII activity.
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影响因子：
15.9
作者：
LAFAYETTE, RA;MAYER, G;MEYER, TW
通讯作者：
MEYER, TW
活动性和缓解性狼疮性肾炎的肾小球损伤程度：理论分析。
DOI：
10.1152/ajprenal.1991.260.5.f717
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Myers,BD;Chagnac,A;Golbetz,H;Newton,L;Strober,S;Sibley,RK
通讯作者：
Sibley,RK
人膜性肾小球病肾小球毛细血管损伤的性质。
DOI：
10.1172/jci112384
发表时间：
1986
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Shemesh,O;Ross,JC;Deen,WM;Grant,GW;Myers,BD
通讯作者：
Myers,BD
用聚蔗糖测定正常大鼠的肾小球尺寸选择性。
DOI：
10.1681/asn.v32214
发表时间：
1992
期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
--
作者：
Oliver3rd,JD;Anderson,S;Troy,JL;Brenner,BM;Deen,WH
通讯作者：
Deen,WH
血管紧张素抑制对慢性肾衰竭血管病变的血压独立作用。
影响因子：
19.6
作者：
Kakinuma,Y;Kawamura,T;Bills,T;Yoshioka,T;Ichikawa,I;Fogo,A
通讯作者：
Fogo,A