Fluorescence Dye Loaded Nano-graphene for Multimodal Imaging Guided Photothermal Therapy.
Fluorescence Dye Loaded Nano-graphene for Multimodal Imaging Guided Photothermal Therapy.
复制标题
用于多模态成像引导光热治疗的荧光染料负载纳米石墨烯
作者：
Rong P;Wu J;Liu Z;Ma X;Yu L;Zhou K;Zeng W;Wang W
光声成像（PA）由于其高空间分辨率和高软组织对比度而成为一种新颖的非侵入性成像方式。在此，我们通过π-π堆积将近红外（NIR）荧光染料（CySCOOH）负载到聚乙二醇化氧化石墨烯（GO）表面，以增加GO的近红外吸光度。 PA成像证明，与游离GO-PEG相比，聚乙二醇化GO-CysCOOH（GO-PEG-CysCOOH）显着增强肿瘤部位的PA信号。然后，我们利用GO-PEG-CySCOOH在近红外区域的强光吸收进行体内光热治疗，静脉注射GO-PEG-CySCOOH和低功率激光照射肿瘤后实现了高效的肿瘤消融。我们的研究结果表明，这种基于石墨烯的纳米复合材料可以开发为一种有前途的 PA 成像造影剂和用于成像引导光热治疗的热剂。
Photoacoustic imaging (PA) has emerged as a novel and noninvasive imaging modality owing to its high spatial resolution and high soft tissue contrast. Herein, we loaded a near-infrared (NIR) fluorescence dye (CySCOOH) onto the surface of PEGylated graphene oxide (GO) via π-π stacking to increase the NIR absorbance of GO. The PA imaging proved that PEGylated GO-CysCOOH (GO-PEG-CysCOOH) significantly enhances the PA signal in the tumor site compared with free GO-PEG. We then utilized the strong optical absorbance of GO-PEG-CySCOOH in the NIR region for in vivo photothermal therapy, achieving efficient tumor ablation after intravenous injection of GO-PEG-CySCOOH and low-power laser irradiation on the tumor. Our results indicate that this graphene-based nanocomposite can be developed as a promising contrast agent for PA imaging and a thermal agent for imaging guided photothermal therapy.