Diagnostic Performance of Two Point-of-Care Tests for Anti-HCV Detection
Diagnostic Performance of Two Point-of-Care Tests for Anti-HCV Detection
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DOI：
10.5812/hepatmon.12274
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发表时间：
2013-09-01
影响因子：
0.6
通讯作者：
Schiavon, Leonardo de Lucca
中科院分区：
文献类型：
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作者：
da Rosa, Ligia;Dantas-Correa, Esther Buzaglo;Schiavon, Leonardo de Lucca
背景资料：除了这个问题在公共卫生方面的重要性之外，还缺乏对目前使用的几种用于检测抗-HCV的护理点检测（POCT）的性能进行评估的研究。目的：调查两种用于检测抗-HCV的POCT的性能，并评估阅读时间对诊断性能的影响。患者和方法：共307名受试者被分为三组（1-HCV感染; 2-其他慢性肝病;和3-对照）。在3、5、10、15、20和30分钟时读取POCT HCV Rapid Test Bioeasy（R）和Immuno-Rapido HCV（R）。结果：所有试验均获得有效结果。当与化学发光相比时，两种检测均显示出97.1%的灵敏度和100%的特异性。在不同的阅读时间和其他慢性肝病患者作为对照组进行评估时，没有观察到测试的灵敏度或特异性的变化。结论：在这项研究中评估的POCT表现出较高的灵敏度和特异性，阅读的第三分钟后的性能没有变化。
Background: Besides the great importance of the issue in terms of public health, there is a lack of studies evaluating the performance of several of the currently used point of care tests (POCTs) for the detection of anti-HCV.Objectives: To investigate the performance of two POCTs for anti-HCV detection and to assess the impact of the reading time on diagnostic performance.Patients and Methods: A total of 307 subjects were divided into three groups (1-HCV infected; 2-other chronic liver diseases; and 3-controls). The POCTs HCV Rapid Test Bioeasy (R) and Imuno-Rapido HCV (R) were read at 3, 5, 10, 15, 20 and 30 minutes. The sensitivity and specificity of the POCTs were calculated in relation to anti-HCV detection by chemiluminescence.Results: Valid results were obtained for all tests. When compared to the chemiluminescence, both tests showed sensitivity of 97.1% and specificity of 100%. No changes in the sensitivity or specificity of the tests were observed at different reading times and when patients with other chronic liver diseases were evaluated as a control group.Conclusions: The POCTs evaluated in this study showed high sensitivity and specificity, with no change in the performance after the third minute of reading.