Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis.
Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis.
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DOI：
10.1007/s11655-015-2305-0
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发表时间：
2015-09
影响因子：
2.9
通讯作者：
Wang YJ
中科院分区：
文献类型：
--
作者：
Liang QQ;Shi Q;Wood RW;Xing LP;Wang YJ
类风湿性关节炎（RA）和骨关节炎（OA）是两种最常见的关节疾病，它们具有滑膜炎症和软骨破坏的特征，与大量分解代谢介质和炎性细胞在滑膜间隙和周围软组织中的积聚有关。这些因子如何被清除以及“清除”过程是否有助于关节炎的发病机制尚不清楚。近年来，我们发现小鼠关节周围存在淋巴系统。在RA和OA小鼠模型中，淋巴管生成和淋巴引流功能的阻断加速，而淋巴功能的刺激减弱关节组织病变的严重程度。更重要的是，我们注意到关节炎关节淋巴引流功能障碍与中医“痹”理论之间的相似性，并证明了几种治疗痹病的中药直接影响淋巴内皮细胞的功能。本文就关节炎与关节周围淋巴系统变化的相互作用进行综述，并对中医“痹”理论与关节炎淋巴功能障碍的关系进行探讨。
Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most common joint diseases, and they have characterization of synovial inflammation and cartilage destruction, associated with the accumulation of numerous catabolic mediators and inflammatory cells in the synovial space and surrounding soft tissues. How these factors are cleared and if the “clearance” process contributes to pathogenesis of arthritis are not known. Recently, we found the existence of the peri-articular lymphatic system in mouse joints. The blockade of lymphangiogenesis and lymphatic draining function accelerates while stimulation of lymphatic function attenuates the severity of joint tissue lesions in mouse models of RA and OA. More importantly, we noticed the similarity between the dysfunction of lymphatic drainage in arthritic joints and “Bi” theory of Chinese medicine (CM), and demonstrated that several Bi disease-treated herbal drugs directly affect the function of lymphatic endothelial cells. Here we review the advances about the interactions between joint inflammation and changes in the peri-articular lymphatic system and discuss our view of linking “Bi” theory of CM to lymphatic dysfunction in arthritis.