Retinoic acid signaling pathways
Retinoic acid signaling pathways
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DOI：
10.1242/dev.167502
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发表时间：
2019-07-01
期刊：
影响因子：
4.6
通讯作者：
Duester, Gregg
中科院分区：
文献类型：
--
作者：
Ghyselinck, Norbert B.;Duester, Gregg
视黄酸（RA）是维生素A的代谢产物，是调节脊索动物发育的核RA受体（RAR）的配体。RA-RAR可以激活或抑制关键发育基因的转录。在缺乏RA生成酶或RAR的小鼠和斑马鱼胚胎中进行的遗传研究有助于识别RA功能，揭示RA信号调节许多器官和组织的发育，包括体轴，脊髓，前肢，心脏，眼睛和生殖道。了解RA信号在发育过程中的正常功能将指导RA作为治疗剂改善人类健康的努力。在这里，我们提供了RA信号的概述，并强调其在开发过程中的关键功能。
Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or repress transcription of key developmental genes. Genetic studies in mouse and zebrafish embryos that are deficient in RA-generating enzymes or RARs have been instrumental in identifying RA functions, revealing that RA signaling regulates development of many organs and tissues, including the body axis, spinal cord, forelimbs, heart, eye and reproductive tract. An understanding of the normal functions of RA signaling during development will guide efforts for use of RA as a therapeutic agent to improve human health. Here, we provide an overview of RA signaling and highlight its key functions during development.