Are ions involved in the gating of calcium channels?
Are ions involved in the gating of calcium channels?
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离子是否参与钙通道的门控？
DOI：
10.1126/science.6289432
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Kung,C
中科院分区：
文献类型：
--
作者：
Saimi,Y;Kung,C
钙、锶、钡离子携带的电流通过草履虫电压敏感性钙通道的激活和失活速率不同。这些差异不能归因于由于内部离子浓度、钙通道失活、钾电流激活、表面电荷效应或不完全空间钳制引起的并发症。研究结果表明二价阳离子参与电压驱动的钙通道门控过程。
The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel ofParameciumare different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current activation, surface charge effects, or incomplete space clamping. The findings indicate participation of the divalent cations in the voltage-driven calcium channel gating process.