Antigen contact sites in class I major histocompatibility complex‐restricted, trinitrophenyl‐specific T cell receptors
Antigen contact sites in class I major histocompatibility complex‐restricted, trinitrophenyl‐specific T cell receptors
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I 类主要组织相容性复合物限制性三硝基苯基特异性 T 细胞受体中的抗原接触位点
DOI：
10.1002/eji.1830220335
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发表时间：
1992
影响因子：
5.4
通讯作者：
A. Iglesias
中科院分区：
文献类型：
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作者：
H. Weltzien;S. Hebbelmann;U. Pflugfelder;H. Ruh;B. Ortmann;S. Martin;A. Iglesias
Cloned trinitrophenyl (TNP)‐specific cytotoxic T cells (CTL) were obtained from mice transgenic for the β chain of the antigen‐specific receptor (TcR) of a Kb‐restricted, TNP‐specific CTL clone (BT7.4.1). The transgene‐expressing CTL, specific for TNP/Kb were found to select for TcR α chains highly similar to that of the transgene donor clone BT7.4.1. In that way, two clones (II/7 and III/1) were identified whose TcR differed from the BT7.4.1 receptor only in their Nα‐ and Jα‐sequences, i.e. within the third complementarity‐determining regions of their α chains (CDR3α). Moreover, the TcR of clones II/7 and III/1 had both rearranged the same Jα element, thus differing from each other by only two amino acids in their Vα/Jα junctional regions. Functionally, however, clone III/1 exhibited unique cytolytic specificities for synthetic, Kb‐binding TNP‐peptides as well as for chemically TNP‐modified allogeneic (H‐2k) target cells. These findings demonstrate that (a) similar to “conventional” peptide antigens, synthetic hapten‐peptide determinants are contacted by CDR3α‐determined amino acids of the TcR and (b) in contrast to current models, CDRα also appears to influence the major histocompatibility complex restriction specificity of a given TcR.
两种不同的机制解释了 T 细胞对鸽子细胞色素 c 反应的免疫反应 (Ir) 基因控制。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
McElligott,DL;Sorger,SB;Matis,LA;Hedrick,SM
通讯作者：
Hedrick,SM