Plasma adrenomedullin level and year-by-year variability of body mass index in the general population
Plasma adrenomedullin level and year-by-year variability of body mass index in the general population
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DOI：
10.1016/j.peptides.2021.170567
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发表时间：
2021-05-08
期刊：
影响因子：
3
通讯作者：
Kitamura, Kazuo
中科院分区：
文献类型：
--
作者：
Kato, Johji;Kawagoe, Yukiko;Kitamura, Kazuo
肾上腺髓质素、心房降压肽和 B 型利钠肽（AM、ANP、BNP）的血浆水平可能是心血管疾病的生物标志物。据报道，在一段时间内体重指数（BMI）变异性的增加与心血管疾病的发病率或死亡率有关。本研究的目的是通过分析无明显心血管疾病的一般人群中肽的血浆水平与 BMI 逐年变化之间的关系，来检验这些降血压肽作为生物标志物的临床意义。研究对象是参加年度健康检查的 427 名当地居民（141 名男性和 286 名女性），他们在过去 10 年中至少接受过 5 次检查。根据每个性别的 BMI 值变异系数 (CV) 中位数，将他们分为低变异性和高变异性两组。与BMI逐年变异性较低的人群相比，无论性别，BMI逐年变异性较高的人群的血浆AM水平均显着升高；同时，利尿钠肽的血浆水平没有发现这种差异。两组之间的年龄、BMI、血压或血清肌酐等可能影响血浆AM水平的基础参数没有发现显着差异。总之，在没有明显心脏病的普通人群中，血浆 AM 的增加与 BMI 的逐年高变异性相关。两者之间的这种关系表明，血浆 AM 水平升高是心血管风险标志物。
Plasma levels of the hypotensive peptides of adrenomedullin and atrial and B-type natriuretic peptides (AM, ANP, BNP) are possible biomarkers for cardiovascular diseases. Increased variability of body mass index (BMI) over a certain period of time has been reported to be associated with cardiovascular morbidity or mortality. The aim of this study is to examine clinical significance of those hypotensive peptides as biomarkers by analyzing the relationship between plasma levels of the peptides and year-by-year variability of BMI in the general population without overt cardiovascular diseases. The subjects were 427 local residents (141 males and 286 females) attending their annual health check-up, who had been examined at least 5 times over the preceding period of 10 years. They were divided into two groups of low or high variability by the median of coefficient of variation (CV) of BMI values for each gender. Plasma AM levels of those with high year-by-year variability of BMI were significantly increased, as compared to the group with low variability, in both genders; meanwhile, such a difference was not noted in plasma levels of the natriuretic peptides. No significant differences were found in the basal parameters, which could affect plasma AM level, such as age, BMI, blood pressure or serum creatinine, between two groups. In conclusion, increase in plasma AM was associated with high year-by-year variability of BMI in the general population without overt heart disease. This relationship between the two suggests that increased plasma AM level is a cardiovascular risk marker.