Mechanical verification of soft-tissue attachment on bioactive glasses and titanium implants
Mechanical verification of soft-tissue attachment on bioactive glasses and titanium implants
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DOI：
10.1016/j.actbio.2008.02.012
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发表时间：
2008-07-01
影响因子：
9.7
通讯作者：
Aro, Hannu T.
中科院分区：
文献类型：
--
作者：
Zhao, Desheng;Moritz, Niko;Aro, Hannu T.
软组织附着是许多临床生物材料的理想特征。本研究的目的是设计一种合适的实验方法，用于种植体结合软组织的拉伸测试。用生物活性玻璃(SiO_2-P_2O_5-B_2O_3-Na_2O-K_2O-CaO-MgO)或钛纤维网(孔隙率84.7%)制成锥形种植体。这些植入物被外科手术植入大鼠背部皮下软组织或背部肌肉。种植8周后，用自制夹具进行拔出试验，评价软组织附着情况。钛纤维网状种植体在皮下组织中有较高的拔出力(12.33+/-5.29 N，平均值为+/-SD)，与肌肉组织的附着力也较高(2.46+/-1.33 N)。生物活性玻璃植入物未能显示出与机械相关的软组织结合。力学测试的实验装置对于软组织附着的验证研究似乎是可行的。这种廉价的小动物模型有利于新生物材料的大规模在体筛选。(C)2008 Acta Materialia Inc.由爱思唯尔有限公司出版。版权所有。
Soft-tissue attachment is a desired feature of many clinical biomaterials. The aim of the current study was to design a suitable experimental method for tensile testing of implant incorporation with soft-tissues. Conical implants were made of three compositions of bioactive glass (SiO2-P2O5-B2O3-Na2O-K2O-CaO-MgO) or titanium fiber mesh (porosity 84.7%). The implants were surgically inserted into the dorsal subcutaneous soft-tissue or back muscles in the rat. Soft-tissue attachment was evaluated by pull-out testing using a custom-made jig 8 weeks after implantation. Titanium fiber mesh implants had developed a relatively high pull-out force in subcutaneous tissue (12.33 +/- 5.29 N, mean +/- SD) and also measurable attachment with muscle tissue (2.46 +/- 1.33 N). The bioactive glass implants failed to show mechanically relevant soft-tissue bonding. The experimental set-up of mechanical testing seems to be feasible for verification studies of soft-tissue attachment. The inexpensive small animal model is beneficial for large-scale in vivo screening of new biomaterials. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.