p53 Isoform Δ113p53 in Zebrafish
p53 Isoform Δ113p53 in Zebrafish
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DOI：
10.1089/zeb.2009.0598
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发表时间：
2009-12-01
期刊：
影响因子：
2
通讯作者：
Peng, Jinrong
中科院分区：
文献类型：
--
作者：
Chen, Jun;Peng, Jinrong
P53信号通路除了在肿瘤抑制中发挥重要作用外，还在调节新陈代谢、器官发育和细胞衰老等方面发挥重要作用。最近在p53领域的一个重要进展是发现了体内存在各种不同的P53亚型。虽然众所周知，全长P53可以促进细胞凋亡和细胞周期停滞，但P53亚型在这些过程中的作用仍然不清楚。本文综述了近年来有关P53亚型Delta 113p53在斑马鱼中的调控和功能的研究进展，并讨论了转基因FISH在鉴定参与P53途径的新因子和筛选抗癌新化合物方面的潜在应用。
Apart from playing a crucial role in tumor suppression, the p53 signaling pathway also has important functions in the regulation of metabolism, organ development, and cellular senescence. A recent important advance in the p53 field is the uncovering of presence of various p53 isoforms in vivo. Although full-length p53 is well known to promote cell apoptosis and cell cycle arrest, the roles of p53 isoforms in these processes are still elusive. In this review, we summarized the recent studies on the p53 isoform Delta 113p53 regarding its regulation and function in zebrafish and discussed the potential use of Tg(Delta 113p53:gfp) transgenic fish for identification of novel factors involved in the p53 pathway and for screening of new compounds for cancer therapy.