Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
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DOI：
10.2337/db15-1372
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发表时间：
2016-05-01
期刊：
影响因子：
7.7
通讯作者：
Lichtenbelt, Wouter D. van Marken
中科院分区：
文献类型：
--
作者：
Hanssen, Mark J. W.;van der Lans, Anouk A. J. J.;Lichtenbelt, Wouter D. van Marken
棕色脂肪组织（BAT）的招募已经成为对抗肥胖和相关代谢并发症的潜在工具。短期冷适应不仅可以增强瘦型人BAT的存在和活性，还可以改善骨骼肌的代谢特征，从而有利于2型糖尿病患者的葡萄糖摄取。在这里，我们研究是否短期的冷适应也引起了这样的适应在10个代谢健康的肥胖男性受试者。通过[F-18]氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描评估，10天的冷适应期导致BAT中冷诱导的葡萄糖摄取增加。BAT活性与年龄呈负相关，与体脂百分比呈类似趋势。此外，BAT中冷诱导的葡萄糖摄入与内脏白色脂肪组织中的葡萄糖摄入呈正相关，尽管内脏和皮下白色脂肪组织仓库中的葡萄糖摄入在冷适应后没有变化。冷诱导的骨骼肌葡萄糖摄取倾向于增加后，冷适应，这是由增加的基础GLUT 4定位在肌膜，通过肌肉活检评估。在驯化期结束时，近端皮肤温度升高，对寒冷的主观反应略有改善。这些对长时间暴露于轻度寒冷的代谢适应可能导致改善葡萄糖代谢或防止肥胖相关的胰岛素抵抗和高血糖症的发展。
Recruitment of brown adipose tissue (BAT) has emerged as a potential tool to combat obesity and associated metabolic complications. Short-term cold acclimation has been shown not only to enhance the presence and activity of BAT in lean humans but also to improve the metabolic profile of skeletal muscle to benefit glucose uptake in patients with type 2 diabetes. Here we examined whether short-term cold acclimation also induced such adaptations in 10 metabolically healthy obese male subjects. A 10-day cold acclimation period resulted in increased cold-induced glucose uptake in BAT, as assessed by [F-18]fluorodeoxyglucose positron emission tomography/computed tomography. BAT activity was negatively related to age, with a similar trend for body fat percentage. In addition, cold-induced glucose uptake in BAT was positively related to glucose uptake in visceral white adipose tissue, although glucose uptake in visceral and subcutaneous white adipose tissue depots was unchanged upon cold acclimation. Cold-induced skeletal muscle glucose uptake tended to increase upon cold acclimation, which was paralleled by increased basal GLUT4 localization in the sarcolemma, as assessed through muscle biopsies. Proximal skin temperature was increased and subjective responses to cold were slightly improved at the end of the acclimation period. These metabolic adaptations to prolonged exposure to mild cold may lead to improved glucose metabolism or prevent the development of obesity-associated insulin resistance and hyperglycemia.