Likelihood formulation of parent-of-origin effects on segregation analysis, including ascertainment
Likelihood formulation of parent-of-origin effects on segregation analysis, including ascertainment
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DOI：
10.1086/324709
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发表时间：
2002-01-01
影响因子：
9.8
通讯作者：
Hodge, SE
中科院分区：
文献类型：
--
作者：
Haghighi, F;Hodge, SE
我们开发了一种基于似然性的方法，用于测试复杂疾病中的起源父母效应。的可能性配方模型的父母的原产地的影响，并允许纳入确定，以及差分男性和女性的确定概率。模拟结果表明，当不考虑确定因素或采用错误的确定模型时，对双亲效应（无论是母本效应还是父本效应）的估计都有偏差。唯一的例外是单一确定，我们证明了忽略确定不偏估计的父母的影响，在一个简单的父母的原产地模型。这些结果强调了在复杂疾病中检测母体效应时考虑确定模型的重要性。
We developed a likelihood-based method for testing for parent-of-origin effect in complex diseases. The likelihood formulations model parent-of-origin effect and allow for incorporation of ascertainment, as well as differential male and female ascertainment probabilities. The results based on simulated data indicated that the estimates of parental effect (either maternal or paternal) were biased when ascertainment was ignored or when the wrong ascertainment model was used. The exception was single ascertainment, in which we proved that ignoring ascertainment does not bias the estimation of parental effect, in a simple parent-of-origin model. These results underscore the importance of considering ascertainment models when testing for parent-of-origin effect in complex diseases.