MEDIAL ARTERIAL CALCIFICATION AND DIABETIC NEUROPATHY
MEDIAL ARTERIAL CALCIFICATION AND DIABETIC NEUROPATHY
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DOI：
10.1136/bmj.284.6320.928
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发表时间：
1982-01-01
影响因子：
105.7
通讯作者：
WATKINS, PJ
中科院分区：
文献类型：
--
作者：
EDMONDS, ME;MORRISON, N;WATKINS, PJ
对20例有严重神经病变的糖尿病患者和20例无神经病变但平均年龄和糖尿病病程相似的糖尿病患者进行足、膝和手的X线检查。所有患者均< 53岁，无外周血管疾病的临床证据。内侧动脉钙化在神经病患者中更常见和广泛，15例发生在足部，8例发生在手部，而对照组分别为4例（P < 0.001）和0例（P < 0.001）。钙化与蛋白尿（P < 0.05）和增殖性视网膜病变（P < 0.02）有一定的相关性，但与神经病变的相关性更强（P < 0.001）。神经病变，交感神经支配的平滑肌的图尼卡中，可能是重要的病因中动脉钙化。
X-ray examinations of the feet, knees and hands were performed on 20 diabetics with severe neuropathy and 20 diabetics with no evidence of neuropathy but with a similar mean age and duration of diabetes. All were < 53 yr old with no clinical evidence of peripheral vascular disease. Medial arterial calcification was more common and extensive in the patients with neuropathy, occurring in the feet in 15 and in the hands in 8 compared with in 4 (P < 0.001) and none (P < 0.001) of the controls, respectively. Although there was some correlation between calcification and both proteinuria (P < 0.05) and proliferative retinopathy (P < 0.02), the association between calcification and neuropathy (P < 0.001) was much stronger. Neuropathy, with sympathetic denervation of the smooth muscle of the tunica media, may be important in the etiology of medial arterial calcification.