UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
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UXT-V1 通过调节复合物 II 的形成来保护细胞免受 TNF 诱导的细胞凋亡
DOI：
10.1091/mbc.e10-10-0827
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发表时间：
2011-04-15
影响因子：
3.3
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Huang Y;Chen L;Zhou Y;Liu H;Yang J;Liu Z;Wang C
本研究发现，UXT -V1通过与肿瘤坏死因子受体相关因子2相互作用，被募集到肿瘤坏死因子受体复合体I中。UXT-V1是一种短半衰期蛋白，其降解促进了凋亡受体复合物II的形成，以响应TNF治疗。这项研究揭示了UXT-V1作为tnf诱导的细胞凋亡的一种新的调节因子。
This study revealed that ubiquitously expressed transcript (UXT)-V1 is recruited to tumor necrosis factor (TNF) receptor complex I by interacting with TNF receptor-associated factor 2. UXT-V1 is a short-half-life protein, the degradation of which facilitates the formation of the apoptotic receptor complex II in response to TNF treatment. This study uncovers UXT-V1 as a novel regulator of TNF-induced apoptosis.