Measuring Apparent Trabecular Structure With pQCT: A Comparison With HR-pQCT
Measuring Apparent Trabecular Structure With pQCT: A Comparison With HR-pQCT
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DOI：
10.1016/j.jocd.2013.03.002
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Giangregorio, Lora
中科院分区：
文献类型：
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作者：
Lala, Deena;Cheung, Angela M.;Giangregorio, Lora
我们评估了外周定量计算机断层扫描（pQCT）测量胫骨超远端皮质厚度、密度和表观骨小梁结构与高分辨率pQCT（HR-pQCT）测量结果的可比性。我们还研究了是否pQCT为基础的骨小梁和皮质测量的准确性提高，减少切片厚度从标准的2.2毫米到1.1和0.6毫米。我们浸入15干胫骨标本在盐水中的密封缸和扫描22 - 5毫米的远端胫骨平台使用pQCT和HR-pQCT。pQCT分别低估了骨皮质厚度（CThc）和骨小梁间距（Tb.Sp）21.4%和72.9%，而骨体积/总体积（BV/TV）和皮质密度（CDen）分别高估了265.8%和13.1%。通过定制软件测量的骨小梁体积骨矿物质密度、骨小梁面积、总面积、皮质厚度具有可比性，但对于CThdlc、Tb.Sp、BV/TV和CDen，成像设备之间的差异随估计值的大小而变化。我们建议有兴趣使用pQCT测量骨骺处表观骨小梁结构或皮质厚度或比较不同器械结果的研究人员或临床医生了解HR-pQCT和pQCT之间的差异。
We evaluated how comparable peripheral quantitative computed tomography (pQCT) measurements of cortical thickness, density, and apparent trabecular structure at the ultradistal tibia were with those measured with high-resolution pQCT (HR-pQCT). We also examined whether the accuracy of the pQCT-based trabecular and cortical measurements improved with reductions in slice thickness from the standard 2.2 mm to 1.1 and 0.6 mm. We immersed 15 dry tibia specimens in saline in a sealed cylinder and scanned 22 5 mm from the distal tibia plateau using pQCT and HR-pQCT. pQCT underestimated cortical thickness by Stratec (CThStratec) and trabecular spacing (Tb.Sp) by 21.4% and 72.9%, whereas bone volume to total volume (BV/TV) and cortical density (CDen) were overestimated by 265.8% and 13.1%, respectively. Measurements of trabecular volumetric bone mineral density, trabecular area, total area, cortical thickness by custom software were comparable, but for CThStratec, Tb.Sp, BV/TV, and CDen, the differences between imaging devices varied with magnitude of the estimate. We recommend that researchers or clinicians interested in using pQCT to measure apparent trabecular structure or cortical thickness at the epiphyses, or in comparing findings from different devices, be aware of the differences between HR-pQCT and pQCT.