Type II NKT Cells and Their Emerging Role in Health and Disease.
Type II NKT Cells and Their Emerging Role in Health and Disease.
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DOI：
10.4049/jimmunol.1601399
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发表时间：
2017-02-01
期刊：
影响因子：
--
通讯作者：
Kumar V
中科院分区：
文献类型：
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作者：
Dhodapkar MV;Kumar V
自然杀伤T（NKT）细胞识别由I类主要组织相容性复合体（MHC）样分子CD1d（CD1家族成员）呈递的脂质抗原。虽然对NKT细胞的大多数早期研究集中在一个具有半恒定T细胞受体（TCR）的亚群，即不变自然杀伤T（iNKT）细胞，但大多数受CD1d限制的脂质反应性人类T细胞表达多样的TCR，被称为II型NKT细胞。这些细胞构成了具有免疫调节特性的循环和组织驻留效应T细胞的独特群体。它们对越来越多的自身及非自身脂质配体产生反应，并且与iNKT细胞以及常规T细胞具有一些共同特性。越来越多的证据表明它们在调节对病原体/肿瘤的免疫以及自身免疫/代谢紊乱中的作用。对这些细胞生物学的更好理解以及操纵其功能的能力可能在多种疾病状况中具有治疗益处。
Natural killer T (NKT) cells recognize lipid antigens presented by a class I MHC-like molecule CD1d, a member of the CD1 family. While most of the initial studies on NKT cells focused on a subset with semi-invariant T cell receptor (TCR) termed iNKT cells, majority of CD1d-restricted lipid-reactive human T cells express diverse TCRs and are termed as type II NKT cells. These cells constitute a distinct population of circulating and tissue-resident effector T cells with immune-regulatory properties. They react to a growing list of self- as well as non-self lipid ligands, and share some properties with both iNKT as well as conventional T cells. Emerging body of evidence points to their role in the regulation of immunity to pathogens/tumors and in autoimmune/metabolic disorders. Improved understanding of the biology of these cells and the ability to manipulate their function may be of therapeutic benefit in diverse disease conditions.