Local tissue anisotropy decreases in cerebellopetal fibers and pyramidal tract in multiple system atrophy
Local tissue anisotropy decreases in cerebellopetal fibers and pyramidal tract in multiple system atrophy
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DOI：
10.1007/s00415-005-0708-0
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发表时间：
2005-05-01
影响因子：
6
通讯作者：
Nakagawa, M
中科院分区：
文献类型：
--
作者：
Shiga, K;Yamada, K;Nakagawa, M
背景多系统萎缩（MSA）的主要特征之一是白色病变：髓鞘丢失、星形细胞增多和胶质细胞胞浆包涵体。组织微结构的病理变化可以改变水分子的扩散行为，这可以通过扩散张量成像（DTI）来评估。目的探讨多发性硬化症（MSA）的白色变性假说。方法对11例临床疑似MSA患者和10例年龄匹配的对照者进行研究。在两组中进行DTI以测量不同感兴趣区域的各向异性分数（FA）：小脑下脚（ICP）、小脑中脚（MCP）、小脑上级脚（SCP）、桥脑基底、内囊和胼胝体。结果MSA组SCP和胼胝体FA值与对照组比较无显著性差异。相比之下，MSA组MCP、脑桥基底和内囊的FA值降低。此外，MCP中的FA值与MSA组的共济失调严重程度呈负相关。结论DTI显示组织各向异性降低的区域与MSA的病理易损区相对应。此外，MCP的局部组织各向异性降低与功能障碍一致。这些观察结果表明，DTI是一种可行的方法，在体内评价的白色物质的病理MSA。
Background One of the cardinal features in multiple system atrophy (MSA) is the white matter pathology: loss of myelin, astrocytosis, and glial cytoplasmic inclusions. The pathological changes of tissue microstructure can modify the diffusion behavior of water molecules, which can be assessed by diffusion tensor imaging (DTI). Objectives To explore the hypothesis of white matter degeneration in MSA. Methods We studied 11 patients with clinically probable MSA and 10 age-matched controls. DTI was performed in both groups to measure fractional anisotropy (FA) in various regions of interest: the inferior cerebellar peduncle (ICP), middle cerebellar peduncle (MCP), superior cerebellar peduncle (SCP), basis pontis, internal capsule, and corpus callosum. Results FA values in SCP and corpus callosum showed no significant difference between the MSA group and controls. By contrast, FA values decreased in the MSA group in the MCP, basis pontis and internal capsule. In addition, FA values in the MCP were negatively correlated with ataxia severity in the MSA group. Conclusion The areas showing decreased tissue anisotropy in DTI corresponded well with pathologically vulnerable areas in MSA. In addition, the local tissue anisotropy of MCP decreased in accordance with functional disability. These observations implied that DTI is a feasible method for in vivo evaluation of the white matter pathology in MSA.