Chemoenzymatic acylation of aminoglycoside antibiotics
Chemoenzymatic acylation of aminoglycoside antibiotics
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DOI：
10.1039/b802248h
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发表时间：
2008-01-01
影响因子：
4.9
通讯作者：
Spencer, Jonathan B.
中科院分区：
文献类型：
--
作者：
Llewellyn, Nicholas M.;Spencer, Jonathan B.
The chemoenzymatic installation of the clinically valuable (S)-4-amino-2-hydroxybutyryl side chain onto a number of 2-deoxystreptamine-containing aminoglycosides is described using the purified Bacillus circulans biosynthetic enzymes BtrH and BtrG in combination with a synthetic acyl-SNAC surrogate substrate.
