RESISTANCE AND SUSCEPTIBILITY OF MICE TO BACTERIAL-INFECTION - COURSE OF LISTERIOSIS IN RESISTANT OR SUSCEPTIBLE MICE
RESISTANCE AND SUSCEPTIBILITY OF MICE TO BACTERIAL-INFECTION - COURSE OF LISTERIOSIS IN RESISTANT OR SUSCEPTIBLE MICE
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DOI：
10.1128/iai.19.3.763-770.1978
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发表时间：
1978-01-01
影响因子：
3.1
通讯作者：
YORK, J
中科院分区：
文献类型：
--
作者：
CHEERS, C;MCKENZIE, IFC;YORK, J
小鼠对单核增生李斯特菌的抗性和易感性与感染后24-48 h内非免疫巨噬细胞的先天杀伤或抑制机体生长的能力以及获得性细胞介导抗性的发生时间有关。耐药C57Bl/6小鼠抑制李斯特菌在肝脏早期生长的效率是敏感BALB/c小鼠的10倍。C57Bl/6小鼠获得性免疫的发生时间比BALB/c小鼠早24-48小时。获得性免疫是通过感染小鼠脾脏和肝脏细菌数量的下降、利用感染小鼠的脾脏细胞将免疫过继转移到正常小鼠、延迟型超敏皮肤试验和脾脏淋巴细胞对氚化胸腺嘧啶的摄取来测量的。
Resistance and susceptibility to Listeria monocytogenes in mice was related to the innate ability of the non-immune macrophages to kill or inhibit the growth of the organism during the 1st 24-48 h after infection and the time of onset of acquired cell-mediated resistance. Resistant C57Bl/6 mice were 10 times more efficient than susceptible BALB/c mice at suppressing the early growth of Listeria in the liver. The onset of acquired immunity occurred 24-48 h earlier in C57Bl/6 than in BALB/c mice. Acquired immunity was measured by fall in bacterial numbers in spleen and livers of infected mice, adoptive transfer of immunity to normal mice by using spleen cells from infected mice, delayed-type hypersensitivity skin testing and uptake of tritiated thymidine by lymphocytes in the spleen.