Vaccines targeting drugs of abuse: is the glass half-empty or half-full?
Vaccines targeting drugs of abuse: is the glass half-empty or half-full?
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DOI：
10.1038/nri3130
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发表时间：
2012-01-01
影响因子：
100.3
通讯作者：
Treweek, Jennifer B.
中科院分区：
文献类型：
--
作者：
Janda, Kim D.;Treweek, Jennifer B.
针对滥用药物的疫苗的出现预示着治疗药物相关疾病的一种根本不同的方法。与针对药物滥用的传统药物疗法不同，疫苗的作用是隔离循环药物并终止药物引起的“快感”，而不会引起不必要的神经调节效应。药物靶向疫苗已进入临床评估阶段，尽管从生物医学的角度来看，这些疫苗显示出希望，但为患者接种疫苗以防止药物滥用的伦理和社会经济影响值得在科学界进行讨论。
The advent of vaccines targeting drugs of abuse heralded a fundamentally different approach to treating substance-related disorders. In contrast to traditional pharmacotherapies for drug abuse, vaccines act by sequestering circulating drugs and terminating the drug-induced 'high' without inducing unwanted neuromodulatory effects. Drug-targeting vaccines have entered clinical evaluation, and although these vaccines show promise from a biomedical viewpoint, the ethical and socioeconomic implications of vaccinating patients against drugs of abuse merit discussion within the scientific community.