Aetio-pathogenesis of breast cancer.
Aetio-pathogenesis of breast cancer.
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DOI：
10.4103/0300-1652.126284
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发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Abdulkareem IH
中科院分区：
文献类型：
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作者：
Abdulkareem IH
乳腺癌是世界上最常见的癌症，也是癌症死亡的第二大原因，尤其是在西方国家，这是一篇关于乳腺癌病因和发病机制的文献综述。其发病机制涉及几个病因学因素，包括年龄，遗传学，家族史，饮食，酒精，肥胖，生活方式，身体活动不足以及内分泌因素。这些因素单独或共同作用于乳腺癌的病因。最近，在某些类别的患者中已经描述了三阴性乳腺癌，并且与传统乳腺癌相比，三阴性乳腺癌与较差的预后和较早的复发相关。因此，充分认识这些因素对识别高危人群和个人非常重要，这将有助于筛查，早期发现和随访。这将有助于降低这种危及生命的疾病的发病率和死亡率。
This is a literature review on the aetiology and pathogenesis of breast cancer, which is the most common cancer worldwide, and the second leading cause of cancer death, especially in Western countries. Several aetiological factors have been implicated in its pathogenesis, and include age, genetics, family history, diet, alcohol, obesity, lifestyle, physical inactivity, as well as endocrine factors. These factors act separately or together in the causation of breast cancer. More recently, triple negative breast cancer has been described in certain categories of patients and is associated with poorer prognosis and earlier recurrence compared with the conventional breast cancer. Therefore, adequate knowledge of these factors is important in identifying high risk groups and individuals, which will help in screening, early detection and follow-up. This will help to decrease the morbidity and mortality from this life-threatening disease.