Sterol metabolism and protein metabolism are differentially correlated with sarcopenia in Asian Chinese men and women.
Sterol metabolism and protein metabolism are differentially correlated with sarcopenia in Asian Chinese men and women.
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DOI：
10.1111/cpr.12989
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发表时间：
2021-04
影响因子：
8.5
通讯作者：
Li DJ
中科院分区：
文献类型：
--
作者：
Li CW;Yu K;Shyh-Chang N;Li GX;Yu SL;Liu HJ;Yang B;Li ZY;Zhao YJ;Xu LY;Xu J;Jiang LJ;Liu RJ;Zhang XY;Li SF;Zhang XW;Xie HY;Li K;Zhan YX;Cui M;Tao HB;Li Y;Liu GS;Ni KM;Li DJ
我们的目的是调查肌肉减少症的患病率和预测变量。我们招募了来自北京协和医院多中心前瞻性纵向肌肉减少症研究（PPLSS）的参与者。使用生物阻抗对肌肉质量进行量化，使用握力和步态速度对肌肉功能进行量化。Logistic回归分析显示，肌肉减少症与营养、生活方式、疾病、心理社会和身体变量的关系。肌肉减少症和肌肉减少性肥胖的患病率分别为9.2%-16.2%和0.26%-9.1%。老年、单身、营养不良、高收入、吸烟、低体力活动、食欲不振和低蛋白饮食与肌肉减少症显著相关。多元逻辑回归分析显示，年龄是所有阶段肌肉减少症的危险因素，80岁以上的参与者对肌肉减少症的易感性增加了5倍以上，而较低的体力活动是一个独立的危险因素。年龄的最佳临界值为71岁，这与普遍接受的60岁临界值不同。女性参与者对肌肉减少症的敏感性比男性参与者低两倍以上。固醇衍生物25-羟基维生素D与男性参与者中肌肉减少症的几率降低四倍相关。一些蛋白质摄入量变量也与肌肉减少症相关。基于这些参数，我们定义了肌肉减少症的高度预测指数。我们的研究结果支持肌肉减少症的预测指数，它聚集了固醇代谢和营养对男性与女性参与者的复杂影响。生物钟基因失调与胶质瘤分级和IDH状态相关。预后模型提示生物钟基因影响胶质瘤进展。GO和GSEA富集分析提示生物钟基因的异常调控可能通过干扰细胞周期和影响免疫细胞浸润而影响胶质瘤的发生。
Our aim was to investigate the prevalence and predictive variables of sarcopenia. We recruited participants from the Peking Union Medical College Hospital Multicenter Prospective Longitudinal Sarcopenia Study (PPLSS). Muscle mass was quantified using bioimpedance, and muscle function was quantified using grip strength and gait speed. Logistic regression revealed the relationships between sarcopenia and nutritional, lifestyle, disease, psychosocial and physical variables. The prevalence of sarcopenia and sarcopenic obesity was 9.2%‐16.2% and 0.26%‐9.1%, respectively. Old age, single status, undernourishment, higher income, smoking, low physical activity, poor appetite and low protein diets were significantly associated with sarcopenia. Multiple logistic regression analysis showed that age was a risk factor for all stages of sarcopenia, and participants above 80 years were greater than fivefold more susceptible to sarcopenia, while lower physical activity was an independent risk factor. The optimal cut‐off value for age was 71 years, which departs from the commonly accepted cut‐off of 60 years. Female participants were greater than twofold less susceptible to sarcopenia than male participants. The sterol derivative 25‐hydroxyvitamin D was associated with fourfold lower odds of sarcopenia in male participants. Several protein intake variables were also correlated with sarcopenia. Based on these parameters, we defined a highly predictive index for sarcopenia. Our findings support a predictive index of sarcopenia, which agglomerates the complex influences that sterol metabolism and nutrition exert on male vs female participants. Dysregulated circadian clock genes were associated with glioma grades and the IDH status. Prognostic model suggests circadian clock genes affect glioma progression. The GO and GSEA enrichment analysis suggested dysregulated circadian clock genes can affect glioma through interfering cell cycle and influencing immunocytes infiltration.
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影响因子：
3.6
作者：
Valenzuela RE;Ponce JA;Morales-Figueroa GG;Muro KA;Carreón VR;Alemán-Mateo H
通讯作者：
Alemán-Mateo H
影响因子：
6.3
作者：
Granic, Antoneta;Mendonca, Nuno;Jagger, Carol
通讯作者：
Jagger, Carol
影响因子：
4
作者：
Oh, Bumjo;Cho, Belong;Cho, Sung-Il
通讯作者：
Cho, Sung-Il
影响因子：
3.8
作者：
Tasar, P. T.;Sahin, S.;Akcicek, F.
通讯作者：
Akcicek, F.
影响因子：
3.9
作者：
Vellas, B.;Fielding, R. A.;Cesari, M.
通讯作者：
Cesari, M.