MATERNAL SERUM TRIGLYCERIDE, GLUCOSE-TOLERANCE, AND NEONATAL BIRTH-WEIGHT RATIO IN PREGNANCY - A STUDY WITHIN A RACIALLY HETEROGENEOUS POPULATION
MATERNAL SERUM TRIGLYCERIDE, GLUCOSE-TOLERANCE, AND NEONATAL BIRTH-WEIGHT RATIO IN PREGNANCY - A STUDY WITHIN A RACIALLY HETEROGENEOUS POPULATION
复制标题
DOI：
10.2337/diacare.18.12.1550
复制
发表时间：
1995-12-01
期刊：
影响因子：
16.2
通讯作者：
BEISCHER, NA
中科院分区：
文献类型：
--
作者：
NOLAN, CJ;RILEY, SF;BEISCHER, NA
目的：探讨妊娠早期血清甘油三酯(TG)水平对预测妊娠晚期糖耐量及新生儿出生体重比(BWR)的价值。研究设计与方法：对388例接受常规产前保健的孕妇进行早早非空腹TG测定(胎龄12+/-6周[Mean+/-SD])与孕晚期(胎龄30+/-3周)50g口服葡萄糖耐量试验(OGTT)测定的糖耐量及BWR的关系进行研究。除澳大利亚/西欧出生的(n=246)和亚洲出生的(n=97)外，对所有女性的数据进行了分析。结果所有受试者的晨间非空腹TG与OGTT曲线下的血糖面积(OGTT-GAUC)呈正相关(r=0.23，P<；0.0001)。这种相关性在妊娠9至12周期间测量TG的受试者中更强(r=0.35P=0.0001)，在这段时间内测量TG的亚洲出生女性中尤其强烈(r=0.71P<；0.0001)。亚洲出生的受试者的平均甘油三酯和2小时和3小时的OGTT值高于澳大利亚和西欧出生的受试者(分别为P=0.004，P<；0.0001和P=0.02)。在所有受试者中，TG与体重呈正相关(r=0.12，P=0.02)，在亚洲出生的受试者中，TG与体重呈正相关(r=0.23，P=0.02)，在妊娠期糖尿病患者中，TG与体重呈正相关(r=0.6，P=0.001)。甘油三酯也是妊娠期糖尿病患者体重比的预测指标。有必要进一步研究早期甘油三酯测定在妊娠期糖尿病筛查和治疗中的作用。亚洲出生的女性和澳大利亚/西欧出生的女性之间存在代谢异质性，其意义尚不清楚，值得进一步研究。
OBJECTIVE - To determine the value of measuring serum triglyceride (TG) levels early in pregnancy for predicting late gestation glucose tolerance and neonatal birth weight ratio (BWR) (birth weight corrected for gestational age).RESEARCH DESIGN AND METHODS - The relationships between morning nonfasting TG measured early in pregnancy (gestational age 12 +/- 6 weeks [mean +/- SD]) and glucose tolerance measured by a 3-h 50-g oral glucose tolerance test (OGTT) late in pregnancy (gestational age 30 +/- 3 weeks) and BWR were investigated in 388 women attending routine antenatal care. The data were analyzed for all women in addition to subgroups of Australian/Western European-born (n = 246) and Asian-born (n = 97) women.RESULTS - Morning nonfasting TG positively correlated with the OGTT glucose area under the curve (OGTT-GAUC) (r = 0.23, P < 0.0001) in all subjects. This correlation was stronger in the subset of subjects who had TG measured between 9 and 12 weeks of gestation (r = 0.35, P = 0.0001) and was particularly strong in Asian-born women who had TG measured within this period (r = 0.71, P < 0.0001). Mean TG and the 2- and 3-h OGTT values were higher in Asian-born subjects compared with Australian/Western European-born subjects (P = 0.004, P < 0.0001, and P = 0.02, respectively). TG correlated positively with BWR in all subjects (r = 0.12, P = 0.02), in Asian born subjects (r = 0.23, P = 0.02), and in subjects with gestational diabetes mellitus (GDM) (r = 0.60, P = < 0.001).CONCLUSIONS - TG, if measured between 9 and 12 weeks of gestation, has moderate predictive value for subsequent glucose tolerance in pregnancy. TG is also predictive of BWR in GDM subjects. Further studies are warranted to investigate the role of early TG measurement in the screening and management of GDM. Metabolic heterogeneity exists between Asian-born and Australian/Western European-born women, the significance of which is still unclear and warrants further study.