Contrasting and convergent patterns of amygdala connectivity in mania and depression: A resting-state study
Contrasting and convergent patterns of amygdala connectivity in mania and depression: A resting-state study
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躁狂症和抑郁症中杏仁核连接的对比和收敛模式：一项静息态研究。
DOI：
10.1016/j.jad.2014.10.044
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发表时间：
2015-03-01
影响因子：
6.6
通讯作者：
Li, Tao
中科院分区：
文献类型：
--
作者：
Li, Mingli;Huang, Chaohua;Li, Tao
背景：双相情感障碍(BP)中的躁郁症和抑郁症表现出两种极端的情绪、生理和行为唤醒状态，尽管在治疗反应和神经认知缺陷方面相似。方法：对18例双相躁狂(BM)患者、10例双相抑郁(BD)患者和28例健康对照进行静息状态功能磁共振扫描。在三组中评估和比较左右杏仁核种子到体素的功能连接性。结果：与健康对照组相比，BM组和BD组双侧杏仁核与额叶下回(眶)、纹状体、右侧舌回和小脑后叶之间的功能连接性均降低。此外，BD患者右侧杏仁核-海马区连接性降低，而BM患者右侧杏仁核-海马区连接性增强。BD和BM患者的功能连接异常强度与临床特征之间无显著相关性。结论：杏仁核与额叶、纹状体、舌叶和小脑区之间的连接障碍模式存在显著重叠，提示情绪状态非依赖性连接。BD和BM患者右侧杏仁核和海马体之间功能连接的对比模式为这两种极端情绪状态可能的机制差异提供了新的原因。(C)2014爱思唯尔B.V.保留所有权利。
Background: wlVlania and depression in bipolar disorder (BP) manifest two extremes of aberrant emotional, physiologic and behavioral arousal states despite similarities in treatment response and neurocognitive deficits. We used resting-state functional magnetic resonance imaging (rsliV1Rl) to explore the common and unique abnormal functional connectivity underlying acute manic or depressed state in BRMethods: 18 Patients with bipolar mania (BM), 10 patients with bipolar depression (BD) and 28 healthy controls underwent resting-state functional magnetic resonance imaging scanning. Left and right amygdala seed-to-voxel based functional connectivity were assessed and compared among the three groups. The relationships between aberrant functional connectivity and the severity of clinical symptoms, number of episodes, illness duration were investigated.Results: Compared to healthy controls, both BM and BD groups showed reduced functional connectivity between bilateral amygdala and inferior frontal gyrus (orbital), striatum, right lingual gyros and posterior cerebellar lobe. Furthermore right amygdala-hippocampal connectivity was decreased in BD but increased in BM. No significant correlations were found between strength of abnormal functional connectivity and clinical characteristic in BD or BM. Limitations: No euthymic subjects were recruited, and the patients in current study were all on medication.Conclusions: The presence of substantial overlap in the pattern of disturbed connectivity between amygdala and frontal, striatal, lingual and cerebellar regions suggests mood state independent clysconnectivity. The contrasting pattern of functional connectivity between right amygclala and hippocarnpus in BD arid BM provides a novel lead to the probable mechanistic differences in these two extremes of mood states. (C) 2014 Elsevier B.V. All rights reserved.