An improved MR imaging technique for the visualization of myocardial infarction
An improved MR imaging technique for the visualization of myocardial infarction
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DOI：
10.1148/radiology.218.1.r01ja50215
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发表时间：
2001-01-01
期刊：
影响因子：
19.7
通讯作者：
Judd, RM
中科院分区：
文献类型：
--
作者：
Simonetti, OP;Kim, RJ;Judd, RM
目的：设计一种用于显示心肌梗死的分段反转恢复快速低角激发(TurboFLASH)磁共振成像脉冲序列，在犬缺血性损伤模型中与其他磁共振成像方法进行比较，并评价其在冠心病患者中的应用价值。在狗身上，用10种不同的脉冲序列产生梗塞并采集图像。在患者中，使用分段TurboFLASH技术在心肌梗死后19天+/-7(SD)获得对比剂增强图像。结果：所有动物和患者在成像时均可看到心肌信号增强的区域。使用增强后分段turboFLASH序列，梗死心肌的信号强度比正常心肌高1,080%+/-214，几乎是测试的次佳序列的两倍，比以前报道的高约10倍。18例心肌梗塞患者均表现为高信号。平均而言，患者心肌高信号区的信号强度比正常心肌高485%+/-43%。结论：节段性反转-恢复TurboFLASH序列在动物心肌局部信号强度差异最大。这项技术在脑梗塞患者中的应用显著改善了受损区域和正常区域之间的区别。
PURPOSE: To design a segmented inversion-recovery turbo fast low-angle shot (turboFLASH) magnetic resonance (MR) imaging pulse sequence for the visualization of myocardial infarction, compare this technique with other MR imaging approaches in a canine model of ischemic injury, and evaluate its utility in patients with coronary artery disease.MATERIALS AND METHODS: Six dogs and 18 patients were examined. In dogs, infarction was produced and images were acquired by using 10 different pulse sequences. In patients, the segmented turboFLASH technique was used to acquire contrast material-enhanced images 19 days +/- 7 (SD) after myocardial infarction.RESULTS: Myocardial regions of increased signal intensity were observed in all animals and patients at imaging. With the postcontrast segmented turboFLASH sequence, the signal intensity of the infarcted myocardium was 1,080% +/- 214 higher than that of the normal myocardium in dogs-nearly twice that of the next best sequence tested and approximately 10-fold greater than that in previous reports. All 18 patients with myocardial infarction demonstrated high signal intensity at imaging. On average, the signal intensity of the high-signal-intensity regions in patients was 485% +/- 43 higher than that of the normal myocardium.CONCLUSION: The segmented inversion-recovery turboFLASH sequence produced the greatest differences In regional myocardial signal intensity in animals. Application of this technique in patients with infarction substantially improved differentiation between injured and normal regions.