EGFR Trafficking in Physiology and Cancer
EGFR Trafficking in Physiology and Cancer
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DOI：
10.1007/978-3-319-96704-2_9
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Sigismund, Sara
中科院分区：
文献类型：
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作者：
Caldieri, Giusi;Malabarba, Maria Grazia;Sigismund, Sara
来自表皮生长因子受体（EGFR）的信号传导引起多种生物学应答，包括细胞增殖、迁移和存活。受体的内吞和运输是重要的生理过程，通过多种机制控制EGFR信号的强度，持续时间，多样化和空间限制，我们在本章中进行了综述。这些机制包括：（i）调节细胞表面的受体密度和活化;（ii）将受体浓缩成不同的新生内吞结构;（iii）将受体定型为不同的内吞途径;（iv）通过不同途径的受体的内体分选和内吞后运输，以及（v）再循环至细胞表面的限制区域。我们还强调了细胞器之间的通信如何控制EGFR活性沿着内吞途径。最后，我们阐明了EGFR致癌突变体的异常运输以及内吞机制的改变如何导致癌症中EGFR信号的异常。
Signaling from the epidermal growth factor receptor (EGFR) elicits multiple biological responses, including cell proliferation, migration, and survival. Receptor endocytosis and trafficking are critical physiological processes that control the strength, duration, diversification, and spatial restriction of EGFR signaling through multiple mechanisms, which we review in this chapter. These mechanisms include: (i) regulation of receptor density and activation at the cell surface; (ii) concentration of receptors into distinct nascent endocytic structures; (iii) commitment of the receptor to different endocytic routes; (iv) endosomal sorting and postendocytic trafficking of the receptor through distinct pathways, and (v) recycling to restricted regions of the cell surface. We also highlight how communication between organelles controls EGFR activity along the endocytic route. Finally, we illustrate howabnormal trafficking of EGFR oncogenic mutants, as well as alterations of the endocytic machinery, contributes to aberrant EGFR signaling in cancer.