Synthesis of One-Component Nanostructured Polyion Complexes via Polymerization-Induced Electrostatic Self-Assembly
Synthesis of One-Component Nanostructured Polyion Complexes via Polymerization-Induced Electrostatic Self-Assembly
复制标题
通过聚合诱导静电自组装合成单组分纳米结构聚离子配合物
DOI：
10.1021/acsmacrolett.8b00005
复制
发表时间：
2018-02-01
影响因子：
7.015
通讯作者：
Cai, Yuanli
中科院分区：
文献类型：
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作者：
Cai, Meng;Ding, Yi;Cai, Yuanli
纳米结构的聚离子复合物（PIC）有望作为一种新的平台，以稳定和提供药物，蛋白质和核酸。然而，传统的自组装缺乏规模化和可重复性。特别是对于单组分PIC，迄今为止只有球体可用。在这里，我们报告了一个有效的和可扩展的战略，准备单组分低维PIC。它涉及在25 ° C下在水中以25%w/w固体进行相反电荷单体的可见光介导的RAFT迭代聚合。球膜囊泡过渡和电荷/介质可调的形状选择性的报告。采用这种新的方法，可以方便地制备单组分PIC纳米线、纳米膜、囊泡、纳米管和表面带电囊泡，并实现囊泡聚合。这一策略提供了一个通用的平台，以制备单组分低维PIC与可定制的形态和高重现性的商业上可行的规模下的生态友好的条件下。
Nanostructured polyion complexes (PICs) are expected to serve as novel platforms to stabilize and deliver drugs, proteins, and nucleic acids. Yet, traditional self-assembly suffers from lack of scale-up and reproducibility. Particularly for one-component PICs, only spheres are available to date. Here, we report an efficient and scalable strategy to prepare one-component low-dimensional PICs. It involves visible-light mediated RAFT iterative polymerization of opposite-charge monomers at 25% w/w solids in water at 25 degrees C. Sphere-film vesicle transition and charge-/medium-tunable shape selectivity are reported. One-component PIC nanowire, ultrathin film, vesicle, tube, and surface-charged vesicle are easily prepared, and vesicle-polymerization is fulfilled, using this new strategy. This strategy provides general platform to prepare one component low-dimensional PICs with tailorable morphologies and high reproducibility on commercially viable scale under ecofriendly conditions.