Epstein-Barr virus-associated gastric carcinoma in southern India: A comparison with a large-scale Japanese series
Epstein-Barr virus-associated gastric carcinoma in southern India: A comparison with a large-scale Japanese series
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DOI：
10.1002/jmv.10215
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发表时间：
2002-11-01
影响因子：
12.7
通讯作者：
Nair, MK
中科院分区：
文献类型：
--
作者：
Kattoor, J;Koriyama, C;Nair, MK
比较了印度和日本这两个胃癌发病率明显不同的国家的EB病毒相关性胃癌的流行病学和临床病理特征。应用原位杂交技术检测了喀拉拉邦、印度和日本的215例和2,011例胃癌组织中EB病毒编码的小RNA(EBER)。印度病例中有10例(5%)呈EBER阳性，均为男性。这一频率与日本系列相似(6.2%)。与日本系列一样，印度系列中EBV相关性胃癌最常见于胃中部(1例位于胃窦，4例位于中段，2例位于贲门，3例不明)，组织学上弥漫型Lauren‘s分型(8例)多于肠型(2例)。用聚合酶链式反应-限制性片段长度多态性进行病毒分型，从EBER阳性印度病例中分离的10株EBV均为A亚型，野生型F为BARN HI F区。在Barn HI I区，8例为C型，其余2例为D型。EBER阳性和阴性病例中，P53过表达的肿瘤发生率均无显著差异。然而，在EBER阴性的肿瘤中，P53过表达的细胞比例显著高于EBER阳性的肿瘤，无论组织学类型如何。总之，印度南部EBV相关性胃癌的发生率和主要临床病理特征与日本的相似，尽管这两个国家的胃癌发病率明显不同。(C)2002年Wiley-Liss，Inc.
Epidemiological and clinicopathological features of Epstein-Barr virus (EBV) associated gastric carcinoma was compared in India and Japan, two countries differing markedly in gastric cancer incidence. Using in situ hybridization assay, the presence of EBV-encoded small RNA (EBER) was examined in 215, and 2,011 gastric cancer cases in Kerala, India, and Japan, respectively. Ten cases (5%), all males, in the Indian series were EBER-positive. This frequency was similar to that in the Japanese series (6.2%). As was the case with Japanese series, the EBV-associated gastric carcinoma in the Indian series was observed most frequently in the middle part of the stomach (1 in antrum, 4 in middle part, 2 in cardia, and 3 unknown), and, histologically, the diffuse type Lauren's classification (8 cases) was more common than the intestinal type (2 cases). Virus subtyping by PCR-RFLP revealed that all of the 10 EBV strains isolated from the EBER-positive Indian cases were subtype A, and wild-type F for Barn HI F region. In Barn HI I region, 8 cases were type C and the remaining 2 cases were type D. In either series, there was no significant difference in the frequency of tumors with p53 overexpression between EBER-positive and -negative cases. However, the proportion of cells with p53 overexpression in EBER-negative tumors was significantly higher than that in EBER-positive tumors regardless of histological type in both series. In conclusion, the frequency and major clinicopathological features of EBV-associated gastric carcinoma in south India were similar to those observed in Japanese series although gastric cancer incidence in these two countries differs markedly. (C) 2002 Wiley-Liss, Inc.