Longitudinal profiles of back pain across adulthood and their relationship with childhood factors: evidence from the 1946 British birth cohort.
Longitudinal profiles of back pain across adulthood and their relationship with childhood factors: evidence from the 1946 British birth cohort.
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DOI：
10.1097/j.pain.0000000000001143
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发表时间：
2018-04
期刊：
影响因子：
7.4
通讯作者：
Cooper R
中科院分区：
文献类型：
--
作者：
Muthuri SG;Kuh D;Cooper R
补充数字内容在文本中可用。在英国的一项出生队列研究中，确定了4种不同的长期背痛特征，每一种都与不同的早期生活风险因素有关。本研究的目的是（1）研究成年后背痛的长期特征，（2）研究儿童期风险因素是否与这些特征相关，使用来自医学研究理事会全国健康与发展调查的3271名参与者的数据。对31岁、36岁、43岁、53岁、60至64岁和68岁时背痛的二元结局进行了纵向潜在类别分析。使用多项逻辑回归模型来检查选定的儿童期风险因素和班级成员之间的关联;调整性别，成人体型，健康状况和行为，社会经济地位和背痛家族史。确定了四种背痛类型：无或偶尔疼痛（57.7%），仅成年早期（16.1%），成年中期发作（16.9%）和持续性（9.4%）。在随后的分析中，“无或偶尔”特征被视为参考类别。经过调整后，7岁时较高的身高与成年早期的可能性仅相关（身高每增加1 SD的相对风险比= 1.31 [95%置信区间：1.05-1.65]）和持续性疼痛（相对风险比= 1.33 [95%置信区间：1.01-1.74]）（性别相互作用P = 0.01）。与男性和女性持续性疼痛风险增加相关的因素是腹痛、儿童期最差的护理和较差的孕产妇健康。腹痛和最差的住房质量也与成年中期发作疼痛的可能性增加有关。这些研究结果表明，背痛有不同的长期特征，每一种都与不同的早期生活风险因素有关。这凸显了早期干预对于预防和管理背痛的潜在重要性。
Supplemental Digital Content is Available in the Text. In a British birth cohort study, 4 distinct long-term back pain profiles were identified, each of which was associated with different early life risk factors. This study aimed to (1) characterise long-term profiles of back pain across adulthood and (2) examine whether childhood risk factors were associated with these profiles, using data from 3271 participants in the Medical Research Council National Survey of Health and Development. A longitudinal latent class analysis was conducted on binary outcomes of back pain at ages 31, 36, 43, 53, 60 to 64, and 68 years. Multinomial logistic regression models were used to examine associations between selected childhood risk factors and class membership; adjusted for sex, adult body size, health status and behaviours, socioeconomic position, and family history of back pain. Four profiles of back pain were identified: no or occasional pain (57.7%), early-adulthood only (16.1%), mid-adulthood onset (16.9%), and persistent (9.4%). The “no or occasional” profile was treated as the referent category in subsequent analyses. After adjustment, taller height at age 7 years was associated with a higher likelihood of early-adulthood only (relative risk ratio per 1 SD increase in height = 1.31 [95% confidence interval: 1.05-1.65]) and persistent pain (relative risk ratio = 1.33 [95% confidence interval: 1.01-1.74]) in women (P for sex interaction = 0.01). Factors associated with an increased risk of persistent pain in both sexes were abdominal pain, poorest care in childhood, and poorer maternal health. Abdominal pain and poorest housing quality were also associated with an increased likelihood of mid-adulthood onset pain. These findings suggest that there are different long-term profiles of back pain, each of which is associated with different early life risk factors. This highlights the potential importance of early life interventions for the prevention and management of back pain.
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DOI：
10.1016/j.berh.2010.10.002
发表时间：
2010-12-01
影响因子：
5.2
作者：
Hoy, D.;Brooks, P.;Buchbinder, R.
通讯作者：
Buchbinder, R.
影响因子：
3
作者：
Hartvigsen, Jan;Christensen, Kaare
通讯作者：
Christensen, Kaare
影响因子：
7.4
作者：
Grunau, RE;Holsti, L;Yu, W
通讯作者：
Yu, W
影响因子：
2.8
作者：
Hestbaek, Lise;Korsholm, Lars;Kyvik, Kirsten Ohm
通讯作者：
Kyvik, Kirsten Ohm
DOI：
10.1001/jama.2016.16885
发表时间：
2016-12-27
期刊：
JAMA
影响因子：
--
作者：
Dieleman JL;Baral R;Birger M;Bui AL;Bulchis A;Chapin A;Hamavid H;Horst C;Johnson EK;Joseph J;Lavado R;Lomsadze L;Reynolds A;Squires E;Campbell M;DeCenso B;Dicker D;Flaxman AD;Gabert R;Highfill T;Naghavi M;Nightingale N;Templin T;Tobias MI;Vos T;Murray CJ
通讯作者：
Murray CJ