Interactions Between Muscle Tissues and Bone Metabolism
Interactions Between Muscle Tissues and Bone Metabolism
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DOI：
10.1002/jcb.25040
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发表时间：
2015-05-01
影响因子：
4
通讯作者：
Kaji, Hiroshi
中科院分区：
文献类型：
--
作者：
Kawao, Naoyuki;Kaji, Hiroshi
肌肉减少症和骨质疏松症最近被指出与运动综合征和老年人数量增加有关。肌肉减少症定义为肌肉质量减少和肌肉功能受损，这可能与虚弱有关。一些临床数据表明，肌肉质量的增加与骨量的增加和骨折风险的降低有关。遗传、内分泌和机械因素以及炎症和营养状态同时影响肌肉组织和骨代谢。在全基因组关联研究（GWAS）中，已经显示包括肌肉生长抑制素和α-辅肌动蛋白3的几个基因与肌肉减少症和骨质疏松症两者相关。维生素D、生长激素和睾丸激素以及病理性疾病，如糖皮质激素过量和糖尿病，都会影响肌肉和骨骼。骨代谢和肌肉生物学的基础和临床研究表明，骨与骨骼肌除了它们的肌肉骨骼功能外，还通过来自局部和体液因素的信号传导相互作用。然而，与肌肉和骨骼相互作用相关的生理和病理机制仍不清楚。我们发现，Tmem 119可能在肌祖细胞向成骨细胞谱系的转化中起关键作用。我们还报道了骨甘氨酸和FAM 5C可能是肌源性体液成骨因子。其他因子，包括肌生长抑制素、骨连接素、胰岛素样生长因子I、鸢尾素和骨钙素，可能与肌肉组织和骨代谢之间的相互作用有关。J.细胞。116：687-695，2015. (C)2014 Wiley Periodicals，Inc.
Sarcopenia and osteoporosis have recently been noted for their relationship with locomotive syndrome and increased number of older people. Sarcopenia is defined by decreased muscle mass and impaired muscle function, which may be associated with frailty. Several clinical data have indicated that increased muscle mass is related to increased bone mass and reduced fracture risk. Genetic, endocrine and mechanical factors as well as inflammatory and nutritional states concurrently affect muscle tissues and bone metabolism. Several genes, including myostatin and a-actinin 3, have been shown in a genome-wide association study (GWAS) to be associated with both sarcopenia and osteoporosis. Vitamin D, growth hormone and testosterone as well as pathological disorders, such as an excess in glucocorticoid and diabetes, affect both muscle and bone. Basic and clinical research of bone metabolism and muscle biology suggests that bone interacts with skeletal muscle via signaling from local and humoral factors in addition to their musculoskeletal function. However, the physiological and pathological mechanisms related to muscle and bone interactions remain unclear. We found that Tmem119 may play a critical role in the commitment of myoprogenitor cells to the osteoblast lineage. We also reported that osteoglycin and FAM5C might be muscle-derived humoral osteogenic factors. Other factors, including myostatin, osteonectin, insulin-like growth factor I, irisin and osteocalcin, may be associated with the interactions between muscle tissues and bone metabolism. J. Cell. Biochem. 116: 687-695, 2015. (C) 2014 Wiley Periodicals, Inc.