Thyroid autoantibodies are not associated with recurrent pregnancy loss
Thyroid autoantibodies are not associated with recurrent pregnancy loss
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DOI：
10.1016/s0002-9378(98)70029-8
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发表时间：
1998-12-01
影响因子：
9.8
通讯作者：
Stagnaro-Green, A
中科院分区：
文献类型：
--
作者：
Esplin, MS;Branch, DW;Stagnaro-Green, A
目的：大约1%的女性有复发性流产，定义为大于或等于3次自发性流产;然而，只有50%的病例确定了原因。最近的研究表明，在没有复发性流产史的妇女中，妊娠前三个月甲状腺自身抗体的存在与当前妊娠的自然流产有关。本研究的目的是确定是否循环甲状腺自身抗体与反复妊娠loss.Study设计：血清从74个nonpregnancy妇女的历史反复妊娠loss和从75个健康，生育控制受试者的类似妊娠进行了测试甲状腺球蛋白和甲状腺过氧化物酶抗体通过放射免疫分析试剂盒。所有妇女都进行了第三代促甲状腺激素测定。样本获得大于或等于6个月后pregnancy.RESULTS：22名妇女的历史反复妊娠丢失（29.3%）和28名对照组（37%）的甲状腺自身抗体的一个或两个阳性结果（P> 0.05）。平均促甲状腺激素水平和比例的妇女与异常的促甲状腺激素值之间没有显着差异2 groups.CONCLUSION：妇女的历史，经常性流产是没有更可能比生育对照组有循环甲状腺自身抗体。抗甲状腺抗体的检测在临床上对有反复流产史的患者的评估没有帮助。
OBJECTIVE: Approximately 1% of all women have recurrent pregnancy loss, defined as greater than or equal to 3 spontaneous losses of pregnancy; however, a cause is determined in only 50% of cases. Recent studies have associated the presence of thyroid autoantibodies during the first trimester of pregnancy with spontaneous abortion in the current pregnancy among women without a history of recurrent abortion. The objective of this study was to determine whether circulating thyroid autoantibodies were associated with recurrent pregnancy loss.STUDY DESIGN: Sera from 74 nonpregnant women with a history of recurrent pregnancy loss and from 75 healthy, fertile control subjects of similar gravidity were tested for thyroglobulin and thyroid peroxidase antibodies by means of radioimmunoassay kits. All women had a third-generation thyroid-stimulating hormone assay performed. Samples were obtained greater than or equal to 6 months after a pregnancy.RESULTS: Twenty-two of the women with a history of recurrent pregnancy loss (29.3%) and twenty-eight of the control subjects (37%) had positive results for either one or both of the thyroid autoantibodies (P>.05). Mean thyroid-stimulating hormone levels and the proportion of women with abnormal thyroid-stimulating hormone Values did not differ between the 2 groups.CONCLUSION: Women with a history of recurrent pregnancy loss are no more likely than are fertile control subjects to have circulating thyroid autoantibodies. Testing for antithyroid antibodies is not clinically useful in the evaluation of patients with a history of recurrent pregnancy loss.