TRYPTOPHAN EXCITED-STATES AND CATARACTS IN HUMAN LENS
TRYPTOPHAN EXCITED-STATES AND CATARACTS IN HUMAN LENS
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DOI：
10.1038/241132a0
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发表时间：
1973-01-01
期刊：
影响因子：
64.8
通讯作者：
BORKMAN, RF
中科院分区：
文献类型：
--
作者：
KURZEL, RB;WOLBARSHT, M;BORKMAN, RF
本文报道了在体外对人眼晶状体的荧光和磷光现象进行的研究，以探讨白内障的形成机理。角膜的光透射率随着波长的减小而迅速减小，并且对于小于293 nm 1 -3的波长基本上为零。这种角膜吸收的重要作用已由Bachem 3证实，他用紫外线诱发豚鼠和家兔的白内障，并提出了一个作用光谱，表明体内白内障产生的效率急剧上升，从293 nm处的零上升到300 nm处的最大值，然后在313 nm处急剧下降，并有一个长尾巴延伸到约365 nm。该作用光谱和角膜吸收光谱如图1所示。
WE present here a study of the fluorescence and phosphorescence of human eye lensesin vitrowith regard to the mechanisms of formation of cataracts. Light transmission by the cornea decreases rapidly with decreasing wavelength, and is essentially zero for wavelengths less than 293 nm1–3. The important effect of this corneal absorption was demonstrated by Bachem3who induced cataracts in guinea-pigs and rabbits with ultraviolet light and presented an action spectrum to show that the efficiency ofin vivocataract production rose steeply, from zero at 293 nm to maximum at 300 nm, and then fell off sharply at 313 nm with a long tail extending to about 365 nm. This action spectrum and the corneal absorption spectrum are shown in Fig. 1.