Substrate Effects on the Formation Process, Structure and Physicochemical Properties of Supported Lipid Bilayers
Substrate Effects on the Formation Process, Structure and Physicochemical Properties of Supported Lipid Bilayers
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DOI：
10.3390/ma5122658
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发表时间：
2012-12
期刊：
影响因子：
3.4
通讯作者：
R. Tero
中科院分区：
文献类型：
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作者：
R. Tero
支撑脂质双分子层是存在于固体基质与水溶液界面的人工脂质双分子层膜。固体基底的表面结构和性质通过基底与双层膜之间1-2 nm厚的水层影响着支撑脂质双层膜的形成过程、流动性、二维结构和化学活性。即使在SiO2/Si和云母表面上，它们是平坦的和生物惰性的，并且最广泛地用作支撑脂质双层的基底，也导致支撑膜的结构和性质的差异。在这篇综述中，我总结了几个例子的衬底结构和性质的影响，在原子和纳米尺度上的固体支持的脂质双层，包括我们最近的报告。
Supported lipid bilayers are artificial lipid bilayer membranes existing at the interface between solid substrates and aqueous solution. Surface structures and properties of the solid substrates affect the formation process, fluidity, two-dimensional structure and chemical activity of supported lipid bilayers, through the 1–2 nm thick water layer between the substrate and bilayer membrane. Even on SiO2/Si and mica surfaces, which are flat and biologically inert, and most widely used as the substrates for the supported lipid bilayers, cause differences in the structure and properties of the supported membranes. In this review, I summarize several examples of the effects of substrate structures and properties on an atomic and nanometer scales on the solid-supported lipid bilayers, including our recent reports.