ncDR: a comprehensive resource of non-coding RNAs involved in drug resistance
ncDR: a comprehensive resource of non-coding RNAs involved in drug resistance
复制标题
ncDR：与耐药性相关的非编码 RNA 的综合资源。
DOI：
10.1093/bioinformatics/btx523
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发表时间：
2017-12-15
期刊：
影响因子：
5.8
通讯作者：
Jiang, Wei
中科院分区：
文献类型：
--
作者：
Dai, Enyu;Yang, Feng;Jiang, Wei
非编码RNA药物基因组学作为个体化治疗的一个很有前景的领域，促进了对某些药物不同个体反应的理解，为临床治疗提供了合理的参考。然而，相关信息散布在已发表的文献中，这给研究人员探索参与耐药的非编码RNA带来了不便。为了解决这一问题，我们通过人工筛选和计算分析，系统地识别、验证和预测了与耐药相关的microRNA和长的非编码RNA。随后，我们构建了一个名为NCDR的综合型知识库，它提供了一个用户友好的界面，可以方便地浏览、可视化、查询和下载数据。鉴于人们对精确医学的兴趣迅速增加，NCDR将显著提高我们对调节性非编码RNA在耐药性中的作用的理解，并有可能成为一种及时和有价值的资源。
As a promising field of individualized therapy, non-coding RNA pharmacogenomics promotes the understanding of different individual responses to certain drugs and acts as a reasonable reference for clinical treatment. However, relevant information is scattered across the published literature, which is inconvenient for researchers to explore non-coding RNAs that are involved in drug resistance. To address this, we systemically identified validated and predicted drug resistance-associated microRNAs and long non-coding RNAs through manual curation and computational analysis. Subsequently, we constructed an omnibus repository named ncDR, which furnishes a user-friendly interface that allows for convenient browsing, visualization, querying and downloading of data. Given the rapidly increasing interest in precision medicine, ncDR will significantly improve our understanding of the roles of regulatory non-coding RNAs in drug resistance and has the potential to be a timely and valuable resource.