Complete heart block with ventricular asystole during left vagus nerve stimulation for epilepsy
Complete heart block with ventricular asystole during left vagus nerve stimulation for epilepsy
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DOI：
10.1016/j.yebeh.2004.05.008
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发表时间：
2004-10-01
影响因子：
2.6
通讯作者：
Vaughn, BV
中科院分区：
文献类型：
--
作者：
Ali, II;Pirzada, NA;Vaughn, BV
迷走神经刺激（VNS）是治疗多种抗癫痫药物（aed）无效的难治性癫痫患者的重要选择。迷走神经与心功能的复杂关系引起了人们对迷走神经刺激可能影响心脏节律和功能的关注。先前的上市前和上市后研究并未显示这是一个重大问题，据报道，慢速心律失常的发生率约为0.1%。我们回顾了三例心室骤停和完全性心脏传导阻滞发生在术中铅试验。这些病例报告的目的是确定与迷走神经刺激相关的特定类型的心脏异常，并确定处于危险中的个体。(C) 2004爱思唯尔公司版权所有。
Vagus nerve stimulation (VNS) is an important therapeutic option for individuals with refractory epilepsy who have failed multiple antiepileptic drugs (AEDs). The intricate relationship of the vagus nerve to cardiac function raises concern that vagal stimulation may affect cardiac rhythm and function. Previous pre- and postmarketing studies have not shown this to be a significant problem, with the incidence of bradyarrhythmias reported to be about 0.1%. We review three cases of ventricular asystole with complete heart block that occurred during intraoperative lead tests. The purpose of these case reports is to identify the specific type of cardiac abnormality associated with vagus nerve stimulation and to identify individuals at risk. (C) 2004 Elsevier Inc. All rights reserved.