Visualization of hemodynamics in intracranial arteries using time-resolved three-dimensional phase-contrast MRI
Visualization of hemodynamics in intracranial arteries using time-resolved three-dimensional phase-contrast MRI
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DOI：
10.1002/jmri.20828
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发表时间：
2007-03-01
影响因子：
4.4
通讯作者：
Sakahara, Harumi
中科院分区：
文献类型：
--
作者：
Yamashita, Shuhei;Isoda, Haruo;Sakahara, Harumi
目的：应用时间分辨三维相位对比(PC)-磁共振成像(4D-FLOW)技术对6例健康志愿者(22~50岁，平均30岁)的颅内动脉进行磁共振成像。413-FLOW基于射频(RF)破坏的梯度回波序列，并沿所有三个空间方向进行速度编码(VENC)。测量结果回溯至心电图，并生成电影系列的三维(3D)数据集。体素大小为1×1×1 mm，采集时间30~40min。利用流动可视化软件将4D数据集计算成三维流线、三维粒子轨迹和二维速度矢量场的时间分辨图像。结果：我们能够看到大脑中动脉(MCAS)从Willis环到两侧M2段的三维流线。3D颗粒示踪的时间分辨率图像也清楚地显示了颅内动脉的血流动力学。二维速度矢量场在穿过颈动脉虹吸或基底动脉尖端的平面上清晰可见。这些结果是在所有六名志愿者身上获得的。
Purpose: To visualize the hemodynamics of the intracranial arteries using time-resolved three-dimensional phase-contrast (PC)-MRI (4D-Flow).Materials and Methods: MR examinations were performed with a 1.5T MR unit on six healthy volunteers (22-50 years old, average = 30 years). 413-Flow was based on a radiofrequency (RF)-spoiled gradient-echo sequence, and velocity encoding (VENC) was performed along all three spatial directions. Measurements were retrospectively gated to the electrocardiogram (ECG), and cine series of three-dimensional (3D) data sets were generated. The voxel size was 1 x 1 x 1 mm, and acquisition time was 30-40 minutes. 4D data sets were calculated into time-resolved images of 3D streamlines, 3D particle traces, and 2D velocity vector fields by means of flow visualization software.Results: We were able to see the 3D streamlines from the circle of Willis to the bilateral M2 segment of the middle cerebral arteries (MCAs). Time-resolved images of 3D particle traces also clearly demonstrated intracranial arterial flow dynamics. 2D velocity vector fields on the planes traversing the carotid siphon or the basilar tip were clearly visualized. These results were obtained in all six volunteers.