Differential effects on delayed non-matching-to-position in rats of microinjections of muscarinic receptor antagonist scopolamine or NMDA receptor antagonist MK-801 into the dorsal or ventral extent of the hippocampus.
Differential effects on delayed non-matching-to-position in rats of microinjections of muscarinic receptor antagonist scopolamine or NMDA receptor antagonist MK-801 into the dorsal or ventral extent of the hippocampus.
复制标题
将毒蕈碱受体拮抗剂东莨菪碱或 NMDA 受体拮抗剂 MK-801 微量注射到海马背侧或腹侧，对大鼠延迟位置不匹配的不同影响。
DOI：
10.1016/s0006-8993(97)00426-5
复制
发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
Mao,JB
中科院分区：
文献类型：
--
作者：
Robinson,JK;Mao,JB
谷氨酸能NMDA和胆碱能毒蕈碱受体被认为有助于海马介导的认知过程。来自病变研究的证据表明，尽管海马内的细胞结构均匀，但信息处理沿着隔颞轴可能不均匀。本研究探讨是否在海马亚区的NMDA或毒蕈碱受体的封锁产生区域分离的操作性，空间延迟非匹配位置（DNMTP）的范式，也评估警惕的性能中断。对大鼠进行广泛的DNMTP预训练，然后将双侧插管插入背侧或腹侧海马。再训练后，在训练前给予东莨菪碱或MK-801。MK-801给药到背侧海马产生延迟非依赖性缺陷DNMTP延迟选择。东莨菪碱给药到背侧或腹侧海马，也没有MK-801给药到腹侧海马，产生显着中断DNMTP延迟选择。然而，在其他警戒措施中，一些分离是明显的。东莨菪碱进入背侧和腹侧海马增加遗漏错误，东莨菪碱进入腹侧海马降低样本反应准确性，MK-801进入背侧海马降低样本反应准确性并增加反应偏倚。这些结果是一致的建议，海马的亚区可能参与不同方面的信息处理，也表明，胆碱能输入到海马可能是功能独立的NMDA受体介导的神经传递。
Glutamatergic NMDA and cholinergic muscarinic receptors are thought to contribute to cognitive processes mediated by the hippocampus. Evidence from lesion studies suggests that, despite cytoarchitectural uniformity within the hippocampus, information processing may not be uniform along the septo-temporal axis. The present study examined whether blockade of NMDA or muscarinic receptors in hippocampal subregions produced regional dissociations in the disruption of performance on an operant, spatial delayed non-matching-to-position (DNMTP) paradigm that also assessed vigilance. Rats were extensively pretrained on DNMTP, then bilaterally cannulated into either the dorsal or ventral hippocampus. Following retraining, scopolamine or MK-801 were administered prior to sessions. MK-801 administered into dorsal hippocampus produced delay-independent deficits in DNMTP delayed choice. Neither scopolamine administered into the dorsal or ventral hippocampus, nor MK-801 administered into the ventral hippocampus, produced significant disruption of DNMTP delayed choice. However, some dissociations were evident in other measures of vigilance. Scopolamine into the dorsal and ventral hippocampus increased errors of omission, scopolamine into the ventral hippocampus decreased sample response accuracy, and MK-801 into the dorsal hippocampus decreased sample response accuracy and increased response bias. These results are consistent with the suggestion that subregions of the hippocampus may be involved in different aspects of information processing and also suggest that the cholinergic inputs to the hippocampus may be functionally independent of NMDA receptor-mediated neurotransmission.