Involvement of X-chromosome Reactivation in Augmenting Cancer Testis Antigens Expression: A Hypothesis
Involvement of X-chromosome Reactivation in Augmenting Cancer Testis Antigens Expression: A Hypothesis
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DOI：
10.1007/s11596-018-1842-0
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发表时间：
2018-03
影响因子：
2.4
通讯作者：
Chang Liu;Bin Luo;Xiao-xun Xie;Xing-sheng Liao;Jun Fu;Ying-ying Ge;Xi-sheng Li;Gao-shui Guo;Ning Shen;S. Xiao;Qingmei Zhang
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作者：
Chang Liu;Bin Luo;Xiao-xun Xie;Xing-sheng Liao;Jun Fu;Ying-ying Ge;Xi-sheng Li;Gao-shui Guo;Ning Shen;S. Xiao;Qingmei Zhang
睾丸癌抗原（cta）因其肿瘤特异性表达而成为肿瘤免疫治疗的重要靶点。由于超过一半的确诊CTA位于x染色体上，我们询问CTA表达与x染色体之间是否存在联系。最近的报道表明，失活x染色体的再激活，即x染色体再激活（XCR），是存在于许多女性高危肿瘤中的一种独特现象，可以将许多x连锁基因的表达从单等位基因转变为双等位基因。在这篇综述中，我们讨论了CTA和XCR之间的联系，希望为肿瘤生物学提供一些新的见解。
Cancer testis antigens (CTAs) are attractive targets for tumor immunotherapy because of their tumor-specific expression. Since more than half of confirmed CTAs are located on the X-chromosome, we asked whether there is a link between CTA expression and X-chromosomes. Recent reports have shown that reactivation of the inactive X-chromosome, known as X-chromosome reactivation (XCR), a unique phenomenon that exists in many high-risk tumors in women, can transform the expression of many X-linked genes from monoallelic to biallelic. In this review, we discuss the link between CTA and XCR with the hopes of providing some novel insights into tumor biology.