Emerging mechanisms of dynein transport in the cytoplasm versus the cilium.
Emerging mechanisms of dynein transport in the cytoplasm versus the cilium.
复制标题
DOI：
10.1042/bst20170568
复制
发表时间：
2018-08-20
影响因子：
3.9
通讯作者：
Roberts AJ
中科院分区：
文献类型：
--
作者：
Roberts AJ
两类动力蛋白在不同的细胞环境中为长距离货物运输提供动力。细胞质动力蛋白-1 负责向细胞内部微管负端的大部分运输。 Dynein-2，也称为鞭毛内运输动力蛋白，沿着真核纤毛和鞭毛的轴丝移动货物。两种动力蛋白均作为大型 ATP 驱动的运动复合体发挥作用，其功能障碍与一组人类疾病有关。但它们的作用和调节机制有多相似？为了研究这个问题，本综述重点介绍了 dynein-1 和 -2 研究的最新进展，并探讨了 dynein-1 运输的新兴原理在多大程度上适用于不太了解的 dynein-2 机械酶或与之不同。
Two classes of dynein power long-distance cargo transport in different cellular contexts. Cytoplasmic dynein-1 is responsible for the majority of transport toward microtubule minus ends in the cell interior. Dynein-2, also known as intraflagellar transport dynein, moves cargoes along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances in dynein-1 and -2 research, and probes to what extent the emerging principles of dynein-1 transport could apply to or differ from those of the less well-understood dynein-2 mechanoenzyme.