The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: a retrospective cohort study.
The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: a retrospective cohort study.
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DOI：
10.1186/s12887-016-0673-z
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发表时间：
2016-08-20
期刊：
影响因子：
2.4
通讯作者：
Spergel JM
中科院分区：
文献类型：
--
作者：
Hill DA;Grundmeier RW;Ram G;Spergel JM
儿童过敏性疾病的发病率正在发生变化，因此需要继续监测。基于医疗保健提供者的诊断数据的检查是补充依赖于参与者报告的现有研究所需的重要且缺乏的方法。利用我们的1，050，061名城市和郊区儿童的护理网络，我们定义了两个回顾性队列：（1）29，662名儿童的封闭出生队列和（2）333，200名儿童的横断面队列。这些队列用于确定所研究疾病的流行病学特征。Logistic回归分析用于确定食物过敏与呼吸道过敏的相关程度。在我们的出生队列中，湿疹、哮喘、鼻炎和食物过敏诊断的高峰年龄分别为0至5个月（7.3%）、12至17个月（8.7%）、24至29个月（2.5%）和12至17个月（1.9%）。在我们的横断面队列中，湿疹和鼻炎的患病率分别为6.7%和19.9%。哮喘患病率为21.8%，高于先前报告的患病率。食物过敏患病率为6.7%，最常见的过敏性食物是花生（2.6%）、牛奶（2.2%）、鸡蛋（1.8%）、贝类（1.5%）和大豆（0.7%）。食物过敏与哮喘（OR 2.16，95% CI 1.94-2.40）和鼻炎（OR 2.72，95% CI 2.45-3.03）的发生相关。与以前的报告相比，我们测量到湿疹的发病率较低，哮喘的发病率较高。主要过敏性食物的分布与以前的数据不同，食物过敏与呼吸道过敏的发生有关。利用基于提供者的诊断数据有助于补充现有研究的重要和缺乏的方法。本文的在线版本（doi：10.1186/s12887-016-0673-z）包含补充材料，可供授权用户使用。
The rates of childhood allergic conditions are changing, prompting the need for continued surveillance. Examination of healthcare provider-based diagnosis data is an important and lacking methodology needed to complement existing studies that rely on participant reporting. Utilizing our care network of 1,050,061 urban and sub-urban children, we defined two retrospective cohorts: (1) a closed birth cohort of 29,662 children and (2) a cross-sectional cohort of 333,200 children. These cohorts were utilized to determine the epidemiologic characteristics of the conditions studied. Logistic regression was utilized to determine the extent to which food allergy was associated with respiratory allergy. In our birth cohort, the peak age at diagnosis of eczema, asthma, rhinitis, and food allergy was between 0 and 5 months (7.3 %), 12 and 17 months (8.7 %), 24 and 29 months (2.5 %), and 12 and 17 months (1.9 %), respectively. In our cross-sectional cohort, eczema and rhinitis prevalence rates were 6.7 % and 19.9 %, respectively. Asthma prevalence was 21.8 %, a rate higher than previously reported. Food allergy prevalence was 6.7 %, with the most common allergenic foods being peanut (2.6 %), milk (2.2 %), egg (1.8 %), shellfish (1.5 %), and soy (0.7 %). Food allergy was associated with development of asthma (OR 2.16, 95 % CI 1.94-2.40), and rhinitis (OR 2.72, 95 % CI 2.45-3.03). Compared with previous reports, we measure lower rates of eczema and higher rates of asthma. The distribution of the major allergenic foods diverged from prior figures, and food allergy was associated with the development of respiratory allergy. The utilization of provider-based diagnosis data contributes an important and lacking methodology that complements existing studies. The online version of this article (doi:10.1186/s12887-016-0673-z) contains supplementary material, which is available to authorized users.