Functionally separated networks for self-paced and externally-cued motor execution in Parkinson's disease: Evidence from deep brain recordings in humans
Functionally separated networks for self-paced and externally-cued motor execution in Parkinson's disease: Evidence from deep brain recordings in humans
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DOI：
10.1016/j.neuroimage.2018.05.012
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发表时间：
2018-08-15
期刊：
影响因子：
5.7
通讯作者：
Imbach, Lukas L.
中科院分区：
文献类型：
--
作者：
Bichsel, Oliver;Gassert, Roger;Imbach, Lukas L.
空间分离的皮质基底神经节网络已被提出用于控制目标导向和习惯性行为。在帕金森病中，调节感觉运动（习惯性）行为的多巴胺能神经元的选择性丧失可能因此主要导致习惯性运动控制的缺陷，而目标导向运动的控制相对保留。根据这一假设，我们研究了帕金森病患者的皮质基底神经节网络的电生理学，分别在自起搏和外部提示的手指敲击过程中模拟习惯性和目标导向的运动控制，同时记录丘脑底核（STN）和表面EEG中的局部场电位。只有外部线索的运动诱导的促动事件相关的β-desertification，而β-振荡持续抑制在自步速运动。连通性分析显示，较高的同步性（相位锁定值）之间的额叶和中央电极在自起搏和较高的额叶相位锁定在外部线索的运动。我们的数据提供了直接的电生理支持的存在功能分离的皮质基底神经节网络控制运动行为的帕金森患者，并证实了帕金森患者的假设从习惯性转向目标导向的行为。
Spatially segregated cortico-basal ganglia networks have been proposed for the control of goal-directed and habitual behavior. In Parkinson's disease, selective loss of dopaminergic neurons regulating sensorimotor (habitual) behavior might therefore predominantly cause deficits in habitual motor control, whereas control of goal-directed movement is relatively preserved. Following this hypothesis, we examined the electrophysiology of cortico-basal ganglia networks in Parkinson patients emulating habitual and goal-directed motor control during self-paced and externally-cued finger tapping, respectively, while simultaneously recording local field potentials in the subthalamic nucleus (STN) and surface EEG. Only externally-cued movements induced a pro-kinetic event-related beta-desynchronization, whereas beta-oscillations were continuously suppressed during self-paced movements. Connectivity analysis revealed higher synchronicity (phase-locking value) between the STN and central electrodes during self-paced and higher STN to frontal phase-locking during externally-cued movements. Our data provide direct electrophysiological support for the existence of functionally segregated cortico-basal ganglia networks controlling motor behavior in Parkinson patients, and corroborate the assumption of Parkinson patients being shifted from habitual towards goal-directed behavior.