Regulation of Hippo Signaling by Mechanical Signals and the Cytoskeleton
Regulation of Hippo Signaling by Mechanical Signals and the Cytoskeleton
复制标题
机械信号和细胞骨架对河马信号传导的调节
DOI：
10.1089/dna.2019.5087
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发表时间：
2020
影响因子：
3.1
通讯作者：
Xiaotao Wu
中科院分区：
文献类型：
--
作者：
Cong Zhang;Feng Wang;Zengxin Gao;Pei Zhang;Jiawei Gao;Xiaotao Wu
Hippo信号调节细胞增殖和凋亡之间的平衡，以控制发育过程中器官的大小。适当的Hippo信号传导与干细胞分化相关，而不适当的信号传导可导致肿瘤发生和癌症。Hippo信号传导活性不仅受到生化信号的影响，还受到机械力和通过细胞-细胞连接和细胞-基质粘附传递的细胞骨架的影响。在这篇综述中，我们描述的证据，通过空间重组的信号组件，机械力，和细胞骨架的河马信号的调节。虽然我们对Hippo信号转导和机械力与细胞骨架之间的关系的理解正在迅速发展，但仍有许多未解决的问题。
Hippo signaling regulates the balance between cell proliferation and apoptosis to control the size of organs during development. Appropriate Hippo signaling is associated with stem cell differentiation, and inappropriate signaling can result in tumorigenesis and cancer. Hippo signaling activity is influenced not only by biochemical signals but also by mechanical force and the cytoskeleton transmitted through cell–cell junctions and cell–matrix adhesions. In this review, we describe the evidence for the regulation of Hippo signaling by the spatial reorganization of signaling components, mechanical force, and the cytoskeleton. Although our understanding of the relationship between Hippo signal transduction and mechanical force and the cytoskeleton is developing rapidly, many unresolved questions remain.