Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron:: balance between curing and sparing
Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron:: balance between curing and sparing
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DOI：
10.1088/0031-9155/53/4/003
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发表时间：
2008-02-21
影响因子：
3.5
通讯作者：
Bravin, Alberto
中科院分区：
文献类型：
--
作者：
Regnard, Pierrick;Le Duc, Geraldine;Bravin, Alberto
这项工作的目的是了解ESRF的微束放射治疗，以便在治疗肿瘤和保留正常组织之间找到最佳折衷方案，更好地了解生存曲线并报告其效率。这种方法使用同步加速器产生的x射线微光束。大鼠植入9L胶质瘤，MRI诊断肿瘤。植入后14天，用25m m宽的微光束阵列进行单向照射，皮肤入口剂量为625 Gy。比较了采用200 μ m和100 μ m的微光束中心间距的效果。中位生存时间（植入后）分别为40天和67天，间距分别为200和100亩。然而，在100 μ m的辐射间隔中，72%的大鼠表现出异常的临床症状和体重模式，而在200 μ m的辐射间隔中，只有12%的大鼠受到影响。同时，正常脑的组织学病变仅在100 μ m系列中发现。虽然100 μ m和200 μ m系列的寿命分别增加了273%和102%，但200 μ m间隔方案提供了更好的健康组织保护，并且可能与其他放射方式或其他药物联合使用。
The purpose of this work was the understanding of microbeam radiation therapy at the ESRF in order to find the best compromise between curing of tumors and sparing of normal tissues, to obtain a better understanding of survival curves and to report its efficiency. This method uses synchrotron- generated x- ray microbeams. Rats were implanted with 9L gliosarcomas and the tumors were diagnosed by MRI. They were irradiated 14 days after implantation by arrays of 25m m wide microbeams in unidirectional mode, with a skin entrance dose of 625 Gy. The effect of using 200 or 100 mu m center- to- center spacing between the microbeams was compared. The median survival time ( post- implantation) was 40 and 67 days at 200 and 100 mu m spacing, respectively. However, 72% of rats irradiated at 100 mu m spacing showed abnormal clinical signs and weight patterns, whereas only 12% of rats were affected at 200 mu m spacing. In parallel, histological lesions of the normal brain were found in the 100 mu m series only. Although the increase in lifespan was equal to 273% and 102% for the 100 and 200 mu m series, respectively, the 200 mu m spacing protocol provides a better sparing of healthy tissue and may prove useful in combination with other radiation modalities or additional drugs.