Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor
Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor
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DOI：
10.1016/j.febslet.2005.03.087
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发表时间：
2005-05-09
期刊：
影响因子：
3.5
通讯作者：
Sorrentino, S
中科院分区：
文献类型：
--
作者：
Naddeo, N;Vitagliano, L;Sorrentino, S
核糖核酸酶A （RNase A）二聚体最近被发现具有一些特殊的，即非催化性的RNase生物活性，如抗肿瘤和生曲霉活性。到目前为止，这些活性被认为是由于RNase可以逃避胞质RNase抑制剂（cRI）的中和作用。然而，当以定量方式和分子水平研究两种细胞毒性RNase A二聚体与cRI的相互作用时，发现二聚体以高亲和力结合cRI并形成紧密复合物。(c) 2005年欧洲生化学会联合会。Elsevier B.V.版权所有。
Ribonuclease A (RNase A) dimers have been recently found to be endowed with some of the special, i.e., non-catalytic biological activities of RNases, such as antitumor and aspermatogenic activities. These activities have been so far attributed to RNases which can escape the neutralizing action of the cytosolic RNase inhibitor (cRI). However, when the interactions of the two cytotoxic RNase A dimers with cRI were investigated in a quantitative fashion and at the molecular level, the dimers were found to bind cRI with high affinity and to form tight complexes. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.